摘要
Summary of main observation and conclusion An operationally simple and safe synthesis of a-haloketones using KBr and KCI as nonhazardous halogen sources is reported.It involves an iron-catalysed reaction of alkenes with KBr/KCl using O2 as terminal oxidant under the irradiation of visible-light.This strategy avoids the risks associated with handling halo-contained electrophiles(Cl2,Br2/NCS,NBS).The process is tolerant to several functional groups,and extended to a range of substituted styrenes in up to 89%yield.A radical reaction pathway is proposed based on control experiments and spectroscopy studies.
基金
We thank the financial support from the National Natural Science Foundation of China(Nos.21622204 and 21772161).
