摘要
目的探讨丹参注射液对急性肺损伤老年患者机械通气后的肺保护疗效以及血流动力学的影响。方法选择2015年11月-2018年11月收治的急性肺损伤老年患者共120例,按随机数字表法分为对照组和观察组,每组均60例,两组患者均给予机械通气。对照组给予常规治疗。观察组在对照组基础上采取丹参注射液静脉滴注,10~20 mL/次,1次/d,连续治疗2周。比较两组血气分析、肺功能、血流动力学。结果治疗2周后,观察组患者的肺泡-动脉氧分压差(AaDO2)、呼吸指数(RI)明显低于对照组以及氧合指数(OI)、用力肺活量(FVC)、第1秒钟用力呼吸量(FEV1)、第1秒用力肺活量占预计值百分比(FEV1%)明显高于对照组(P<0.01);治疗2周后,观察组患者的平均动脉压(MAP)、心率(HR)、心指数(CI)、每搏量指数(SVI)明显高于对照组(P<0.01)。结论丹参注射液能改善急性肺损伤机械通气老年患者的血流动力、动脉血气指标,对肺保护的疗效确切。
Objective To investigate the efficacy of Salvia Miltiorrhiza Injection on the lung protection in elderly patients with acute lung injury after mechanical ventilation and its effect on hemodynamics.Method One hundred and twenty elderly patients with acute lung injury were selected from Nov 2015 to Nov 2018 and randomly divided into the control group and the observation group with 60 patients in each group. Both groups were given mechanical ventilation. Cases in the control group were treated with the routine therapy. The observation group was treated with intravenous drip of Salvia Miltiorrhiza Injection(10~20 mL/time,once a day) for 2 weeks. Blood gas analysis,the lung function and hemodynamics were compared between two groups.Results After 2 weeks’ treatment,alveolar-arterial partial pressure difference(AaDO2) and respiratory index(RI) in the observation group were obviously lower while oxygenation index(OI),forced vital capacity(FVC),forced vital capacity in the first second(FEV1) and percentage of forced vital capacity in the first second(FEV1%) were higher,than those in the control group(P<0.01). After 2 weeks’ treatment,mean arterial pressure(MAP),heart rate(HR),cardiac index(CI) and stroke volume index(SVI) in the observation group were higher than those of the control group(P<0.01).Conclusion Salvia Miltiorrhiza Injection can improve the hemodynamics and arterial blood gas index and has a definite effect for lung protection.
作者
巩玲俊
张静可
GONG Lingjun;ZHANG Jingke(Geriatrics Department,Ningbo Medical Center Li Huili Hospital,Ningbo 315000,Zhejiang,China)
出处
《中华中医药学刊》
CAS
北大核心
2020年第3期216-218,共3页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省医学临床科研基金(2009ZYC26)。
关键词
丹参注射液
机械通气
急性肺损伤
血流动力学
Salvia Miltiorrhiza Injection
mechanical ventilation
acute lung injury
hemorheology
