摘要
目的应用FRAX工具预测桂西地区2型糖尿病患者骨质疏松性骨折风险,评估FRAX工具针对该地区的应用价值及人群适用性。方法选取2015年1月至2015年4月来右江民族医学院附属医院就诊并住院治疗的部分桂西地区2型糖尿病(T2DM)患者198例,后根据纳入标准筛选出67例,并收集骨折风险要素的有关临床资料及骨密度测量T值。依据超声骨密度T值将被选者分为3组,T≥-1为正常组:37例;-2.5<T<-1为减少组:22例;T≤-2.5为疏松组:8例。依据性别分组,男组(n=38),女组(n=29)。依据BMI分组为正常及偏瘦组、过重组、肥胖组。将被选者按年龄以10岁为组距,40岁为下限,79岁为上限分为4组:即(40~49)岁,(50~59)岁,(60~69)岁,(70~79)岁。利用FRAX工具测出10年内主要骨质疏松性的和髋部的骨折发生率,进行组间比较。结果桂西地区不同骨密度(T值)T2DM患者的主要骨质疏松性骨折率(MOF)、髋部骨折风险率(HF)及体质指数(BMI)差异存在统计学意义(P<0.01),HF(P<0.05)在不同的BMI中差异存在统计学意义,MOF在性别(P<0.05)和年龄(P<0.01)中差异存在统计学意义,BMI及T值与骨折风险存在负相关(P<0.01)。结论桂西地区T2DM患者的FRAX评分与BMI、T值存在相关性,且60~69岁女性骨折风险高于男性。
Objective To use FRAX tools to predict the risk of osteoporotic fracture in patients with type 2 diabetes mellitus(T2DM)in western Guangxi,and to evaluate the application value and population applicability of FRAX tools in this region.Methods From January 2015 to April 2015,198 cases of type 2 diabetes mellitus(T2DM)patients from western Guangxi were screened,and 67 cases were selected according to the inclusion criteria.Relevant clinical data of fracture risk factors and bone mineral density measurement T-score were collected.According to the ultrasonic bone mineral density T-score,the selected subjects were divided into 3 groups:37 cases with T-score≥-1 were defined as normal bone density group,22 cases with-2.5<T-score<-1 were considered as low bone density group,and 8 cases with T-score≤-2.5 were considered as osteoporosis group.Groups were divided into male group(n=38)and female group(n=29)according to gender.According to BMI,they were divided into normal and lean group,overweight group and obese group.The candidates were divided into four groups according to their age(the group range was 10 years,40 years was the lower limit,and 79 years was the upper limit):(40-49)years old,(50-59)years old,(60-69)years old,and(70-79)years old.The incidence of major osteoporotic and hip fractures over a 10-year period was estimated by using FRAX and compared between groups.Results There were significant differences in major osteoporotic fracture rate(MOF),risk rate of hip fracture(HF)and body weight standard BMI among T2DM patients with different bone mineral density(T-score)in western Guangxi(P<0.01).HF differed in different BMI(P<0.05),while MOF was different by sex(P<0.05)and age(P<0.01).In addition,BMI and T-score were negatively correlated with fracture rate and had differences(P<0.01).Conclusion FRAX score was correlated with BMI and BMD T-score in patients with T2DM in western Guangxi,and the fracture risk of women aged 60~69 was higher than that of men.
作者
杨埜
陈金忠
李野
唐毓金
刘佳
YANG Ye;CHEN Jinzhong;LI Ye;TANG Yujin;LIU Jia(The Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2020年第4期560-563,577,共5页
Chinese Journal of Osteoporosis
基金
国际课题《IOF对骨量减少人群骨折风险评估(FRAX)前瞻性研究》(IOFCJO-D001)
广西重点研发项目《OLFM4在老年性骨质疏松发生中的作用和机制研究》(2018AB58086)。
