摘要
目的探究急性脑梗死(ACI)患者血清缺血修饰白蛋白(IMA)、脂蛋白相关磷脂酶A2(LP-PLA2)水平变化,并分析患者血清IMA、LP-PLA2水平与病情的相关性。方法选取2017年6月-2018年12月在梧州市红十字会医院确诊的ACI患者122例作为观察组。根据脑梗死面积将观察组122例分为轻度梗死组35例、中度梗死组57例和重度梗死组30例。另选取同期该院健康体检者62例作为对照组。分别检测各组血清IMA、LP-PLA2水平。采用Pearson相关分析观察组血清IMA、LP-PLA2水平与病情的相关性。结果观察组血清IMA、LP-PLA2水平高于对照组(P<0.05)。中重度梗死组、中度梗死组血清IMA、LP-PLA2水平高于轻度梗死组(P<0.05),且重度梗死组高于中度梗死组(P<0.05)。Pearson相关分析显示,患者血清IMA水平与病情(NIHSS分数)呈正相关(r=0.738,P=0.000)。患者血清LP-PLA2水平与病情(NIHSS分数)呈正相关(r=0.671,P=0.000)。结论ACI患者血清IMA、LP-PLA2水平升高。随着梗死面积增大,其血清IMA、LP-PLA2水平越高,且呈正相关。血清IMA、LP-PLA2水平可以作为判断ACI病情的标志物。
Objective To investigate the changes of serum ischemia-modified albumin(IMA)and lipoproteinassociated phospholipase A2(LP-PLA2)levels in patients with acute cerebral infarction(ACI),and to analyze the correlation between the levels of both IMA and LP-PLA2 and the disease.Methods Totaly 122 patients with ACI diagnosed in our hospital were selected as the observation group from June 2017 to December 2018.According to the infarct area,122 patients in the observation group were divided into three subgroups:minor infarct group(n=35),medium infarct group(n=57)and severe infarct group(n=30).62 healthy persons were selected as the control group in the same period.The serum levels of IMA and LP-PLA2 were detected.Pearson correlation analysis was used to observe the correlation between serum IMA,LP-PLA2 and the disease.Results The levels of serum IMA and LPPLA2 in the observation group were higher than those in the control group(P<0.05).The levels of serum IMA and LP-PLA2 in the severe and medium group were higher than those in the minor group(P<0.05).The levels of serum IMA and LP-PLA2 in severe group was higher than that in medium group(P<0.05).Pearson correlation analysis showed that there was a positive correlation between serum IMA level and NIHSS score(r=0.738,P=0.000).There was a positive correlation between serum LP-PLA2 level and NIHSS score(r=0.671,P=0.000).Conclusion The levels of serum IMA and LP-PLA2 in ACI patients increase.The levels of serum IMA and LP-PLA2 were higher and positively correlated with the increase of infarct area.The serum levels of IMA and LP-PLA2 can be used as markers to judge the condition of ACI.
作者
李海凤
黄仁胜
殷炽龙
Hai-feng Li;Ren-sheng Huang;Chi-long Yin(Department of Medical Laboratory,Wuzhou Red Cross Hospital,Wuzhou,Guangxi 543002,China)
出处
《中国现代医学杂志》
CAS
2020年第10期117-120,共4页
China Journal of Modern Medicine
关键词
梗塞
大脑中动脉
白蛋白类
脂蛋白类
磷脂酶A2
infarction,middle cerebral artery
albumins
lipoproteins
phospholipase a2
