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噻氯匹定联合钾通道开放剂对冠状动脉粥样硬化性心脏病患者PCI术后心肌灌注成功率及左心室功能的影响

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摘要 目的探讨噻氯匹定联合钾通道开放剂对冠状动脉粥样硬化性心脏病患者经皮冠状动脉介入(PCI)术后的影响。方法选取本院2018年6月至2019年6月收治的冠状动脉粥样硬化性心脏病患者94例,随机数字表法分为观察组(n=47)与对照组(n=47),均行PCI术治疗,对照组采用噻氯匹定治疗,观察组在对照组基础上联合钾通道开放剂治疗。比较2组心肌灌注成功率、手术前后左心室功能[左室舒张末期容积(LVEDV)、左室射血分数(LVEF)、左室收缩末期容积(LVESV)]、心肌损伤指标[心型脂肪酸结合蛋白(H-FABP)、血清缺氧诱导因子-1α(HIF-1α)]。结果观察组心肌灌注成功率93.62%高于对照组76.60%(P<0.05);术后3个月观察组LVEDV、LVESV低于对照组,LVEF高于对照组(均P<0.05);术后1 d、7 d观察组血清H-FABP、HIF-1α水平均低于对照组(均P<0.05)。结论噻氯匹定联合钾通道开放剂有助于改善冠状动脉粥样硬化性心脏病患者PCI术后心肌灌注,增强左心室功能,降低心肌损伤程度。
作者 王亚丹 范青
出处 《国际医药卫生导报》 2020年第9期1248-1250,共3页 International Medicine and Health Guidance News
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