摘要
目的探讨肿瘤标志物检验在肺癌诊断中的临床价值。方法选取本院于2016年1月至2018年12月收治的136例确诊为肺癌的住院患者及肺良性病变者94例,另选取同期43名健康体检者为对照组。利用电化学发光法分别对细胞角蛋白19片段抗原(CYFRA21-1)、神经元特异性烯醇化酶(NSE)、糖链抗原125(CA125)、癌胚抗原(CEA)水平进行检测,并进行检验。就单项或多项联合在诊断肺癌方面的价值进行计算。结果肺癌组血清CYFRA21-1、NSE、CA125与CEA水平相比健康对照组、肺部良性病变组,均明显偏高(P<0.05)。单项检测:YFRA21-1在肺癌诊断当中的灵敏度最高,即78.46%(51/65),而CEA在腺癌中最高(56.86%,29/51),NSE在小细胞肺癌当中最高(75.00%,15/20)。联合检测:NSE+CA125+CEA的灵敏度在腺癌中最高(78.43%,40/51),NSE+CYFRA21-1+CEA的灵敏度在鳞癌中最高(89.23%,58/65),NSE+CYFRA21-1+CEA在小细胞肺癌中最高(80.00%,16/20)。结论在肺癌诊断中,多种肿瘤标志物联合应用,具有较高的临床价值;肺癌病理类型不同,其肿瘤标志物表达存在差异。
Objective To explore the clinical value of tumor marker test in the diagnosis of lung cancer.Methods From January 2016 to December 2018,136 inpatients with lung cancer and 94 patients with benign pulmonary lesions were selected,and 43 healthy people were selected as control group.The levels of cytokeratin 19 fragment antigen(CYFRA21-1),neuron specific enolase(NSE),CA125 and CEA were detected by electrochemiluminescence.The levels of tumor markers in small cell lung cancer(20 cases),adenocarcinoma(51 cases)and squamous cell carcinoma(65 cases)were compared according to pathological types.Calculate the value of single or multiple combinations in the diagnosis of lung cancer.Results The serum levels of CYFRA21-1,NSE,CA125 in lung cancer group were significantly higher than those in healthy control group and benign lung lesion group(P<0.05).Single test:YFRA21-1 has the highest sensitivity in the diagnosis of lung cancer,i.e.78.46%(51/65),while CEA is the highest in adenocarcinoma(56.86%,29/51),and NSE is the highest in small cell lung cancer(75.00%,15/20).Combined detection:NSE+CA125+CEA had the highest sensitivity in adenocarcinoma(78.43%,40/51),NSE+CYFRA21-1+CEA had the highest sensitivity in squamous cell carcinoma(89.23%,58/65),and NSE+CYFRA21-1+CEA had the highest sensitivity in small cell lung cancer(80.00%,16/20).Conclusion In the diagnosis of lung cancer,the combination of multiple tumor markers has high clinical value.The expression of tumor markers varies with different pathological types of lung cancer.
作者
孙菲
SUN Fei(Jilin Baishan Tonghua Mining(Group)General Hospital,Baishan 134300,China)
出处
《中国医药指南》
2020年第14期45-46,共2页
Guide of China Medicine
关键词
肺癌
肿瘤标志物
检验
癌胚抗原
Lung cancer
Tumor markers
Testing
Carcinoembryonic antigen
