摘要
目的探讨疏风解毒汤配合西药治疗带状疱疹的疗效及对后遗神经痛的影响。方法纳入2016年7月~2019年3月北京市丰台中西医结合医院皮肤科收治的300例带状疱疹患者进行研究。对照组患者接受常规西药治疗,观察组患者在此基础上加用疏风解毒汤。比较两组治疗效果及安全性。结果观察组患者的总有效率高于对照组,差异有统计学意义(P<0.05);观察组患者止疱时间、结痂时间、疼痛消失时间为短于对照组,差异有统计学意义(P<0.05);两组患者治疗后血清TNF-α、IL-10检测结果均低于同组治疗前,IL-2检测结果均高于同组治疗前,差异有统计学意义(P<0.05);观察组患者治疗后血清TNF-α、IL-10检测结果均低于对照组治疗后,IL-2检测结果高于对照组治疗后,差异有统计学意义(P<0.05)。观察组患者治疗后的VAS评分低于对照组,差异有统计学意义(P<0.05);观察组患者后遗神经痛发生率低于对照组,差异有统计学意义(P<0.05);两组患者药物不良反应总发生率比较,差异无统计学意义(P>0.05)。结论疏风解毒汤配合西药治疗带状疱疹疗效确切,可降低免疫反应,减轻疼痛程度,降低后遗神经痛发生率,安全性良好。
Objective To investigate the effect of Shufeng Jiedu decoction combined with western medicine on herpes zoster and sequelae neuralgia.Methods A total of 300 patients with herpes zoster treated in the department of dermatology in our hospital from July 2016 to March 2019 were enrolled in this study.The control group received conventional western medicine treatment,and the observation group were treated with Shufeng Jiedu decoction on the basis of the control group.The treatment effect and safety were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05);The blistering time,crusting time,and pain disappearance time of the observation group were shorter than those of the control group,and the differences were statistically significant(P<0.05);After treatment,the serum tumor necrosis factorα(TNF-α)and interleukin 10(IL-10)test results of the two groups were lower than those before treatment,and the interleukin 2(IL-2)test results of the two groups were higher than those before treatment,and the differences were statistically significant(P<0.05);After treatment,the serum TNF-αand IL-10 test results of the observation group were lower than those of the control group,and the IL-2 test result of the observation group was higher than that of the control group,and the differences were statistically significant(P<0.05).The visual analogue scale(VAS)score of the observation group after treatment was lower than that of the control group,and the difference was statistically significant(P<0.05);The incidence of sequelae neuralgia of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05);There was no significant difference in the overall incidence of adverse drug reactions between the two groups(P>0.05).Conclusion Shufeng Jiedu decoction combined with western medicine in the treatment of herpes zoster has a definite effect,which can reduce the immune response and the incidence of sequelae neuralgia,and relieve the pain with higher safety.
作者
孙晓辉
SUN Xiaohui(Department of Dermatology,Fengtai Integrated Hospital of Traditional Chinese and Western Medicine,Beijing 100072,China)
出处
《中国医药科学》
2020年第7期19-22,共4页
China Medicine And Pharmacy
关键词
带状疱疹
疏风解毒汤
后遗神经痛
炎症因子
疼痛程度
Herpes zoster
Shufeng Jiedu decoction
Sequela neuralgia
Inflammation factors
Degree of pain
