摘要
儿童系统性红斑狼疮(childhood-onset systemic lupus erythematosus,cSLE)特指在18岁之前发病的SLE,在我国小儿全身性结缔组织病中居第二位。与成人SLE相比,cSLE在流行病学、临床表现及治疗方面都有其自身特点。近年来,随着人类基因组学和分子生物学的迅猛发展,对该病的认识也在不断加深,本文对cSLE的病因、表现及治疗最新进展进行梳理和总结,以期更好地认识该病,进而指导临床实践。
Childhood-onset systemic lupus erythematosus(cSLE),which refers to SLE before the age of 18,is the second systemic connective tissue disease in children.Compared with adults,cSLE has its own characteristics in epidemiology,clinical presentation,and treatment.In recent years,with the rapid development of human genomics and molecular biology,the understanding of the disease has been updated.This paper reviewed recent progress in the etiology,manifestation,and treatment of cSLE,so as to better understand this disease and guide clinical practice.
作者
邓江红
李彩凤
DENG Jiang-hong;LI Cai-feng(Depaitment of Rheumatology,Beijing Children,Hospital,Capital Medical University,National Centerfor Children,Health,Beijing 100045,China)
出处
《协和医学杂志》
CSCD
2020年第3期276-282,共7页
Medical Journal of Peking Union Medical College Hospital
关键词
儿童
系统性红斑狼疮
流行病学
临床表现
治疗
childhood
systemic lupus erythematosus
epidemiology
clinical manifestation
treatment
