摘要
目的:探讨血必净注射液治疗严重脓毒症患者的临床效果。方法:选取2017年1月1日-2019年12月31日笔者所在医院收治的严重脓毒症患者378例,随机分为两组,对照组采用常规治疗,研究组在常规治疗基础上给予血必净注射液治疗。对比两组治疗前后凝血功能改善情况、APACHEⅡ评分及治疗4周内病死率。结果:治疗前,两组凝血功能指标及APACHEⅡ评分比较,差异均无统计学意义(P>0.05)。治疗7 d后,两组凝血功能指标均优于治疗前,且研究组凝血功能指标均明显优于对照组,差异均有统计学意义(P<0.05)。治疗后,对照组APACHEⅡ评分为(17.3±4.3)分,显著高于研究组的(14.7±4.0)分,差异有统计学意义(t=6.086,P<0.05)。治疗4周内,对照组病死率为6.35%,显著高于研究组的1.59%,差异有统计学意义(字2=0.018,P<0.05)。结论:在常规治疗基础上增加血必净注射液治疗严重脓毒症患者,有利于改善凝血功能,降低病死率,提高预后质量,具有良好的临床效果。
Objective:To investigate the clinical effect of Xuebijing Injection in the treatment of severe sepsis.Method:A total of 378 patients with severe sepsis admitted to our hospital from January 1,2017 to December 31,2019 were randomly divided into two groups,the control group was treated with routine treatment,and the study group was treated with Xuebijing Injection on the basis of routine treatment.The improvement of coagulation function,APACHEⅡscores before and after treatment and the mortality rate within 4 weeks of the two groups were compared.Result:Before treatment,the coagulation function indexes and APACHEⅡscores were compared between the two groups,and the differences were not statistically significant(P>0.05).After 7 days of treatment,the coagulation function indexes of the two groups were better than those before treatment,and the coagulation function indexes of the study group were significantly better than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the APACHEⅡscore of the control group was(17.3±4.3)points,which was higher than(14.7±4.0)points of the study group,and the difference was statistically significant(t=6.086,P<0.05).Within 4 weeks of treatment,the mortality rate of the control group was 6.35%,which was higher than 1.59%of the study group,and the difference was statistically significant(X^2=0.018,P<0.05).Conclusion:The addition of Xubijing Injection on the basis of routine treatment for the treatment of patients with severe sepsis is beneficial to improve the coagulation function,reduce the mortality rate,and improve the quality of prognosis,which has a good clinical effect.
作者
邵玉
SHAO Yu(Southern Theater General Hospital,Guangzhou 510010,China)
出处
《中外医学研究》
2020年第12期12-14,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
广东省自然科学基金项目(项目编号:2018A0303130319)。
关键词
血必净注射液
脓毒症
凝血功能
预后质量
Xuebijing Injection
Sepsis
Coagulation function
Quality of prognosis
