摘要
目的:研究枸地氯雷他定联合鼻内镜手术对慢性鼻窦炎患者的临床疗效及变态反应、嗅觉功能改善作用分析。方法:选取2017年3月至2018年2月的79例慢性鼻窦炎。按照简单随机分组法分为观察组(n=41)和对照组(n=38),对照组采用鼻内镜手术治疗,观察组在对照组的基础上,采用枸地氯雷他定治疗。观察两组治疗疗效情况,嗅觉、Lund-Mackay、Lund-Kennedy评分,变态反应,炎症反应。结果:治疗后,观察组总有效率显著高于对照组[92.68%(38/41)vs68.42%(26/38)](P<0.05=;嗅觉、Lund-Mackay、Lund-Kennedy评分均显著低于对照组[(2.51±0.70)分vs(4.03±0.92)分,(4.32±0.51)分vs(6.56±0.83)分,(2.46±0.12)分vs(4.03±0.26)分](P<0.05);血清TIgE、ECP均显著低于对照组[(57.98±4.91)kU/L vs(63.75±7.02)kU/L,(4.02±0.50)ng/L vs(5.38±0.92)ng/L](P<0.05);血清TNF-α、IL-6、IL-8水平均显著低于对照组[(1.19±0.52)ng/mL vs(2.70±0.81)ng/mL,(5.10±1.05)pg/mL vs(10.26±2.01)pg/mL,(281.96±30.49)ng/L vs(316.30±42.80)ng/L](P<0.05)。结论:枸地氯雷他定联合鼻内镜手术可改善患者的临床症状,提高鼻腔、鼻窦通气功能,恢复嗅觉功能,减轻变态反应,促进恢复,治疗效果显著。
Objective:To analyze the clinical effect of medloratadine combined with endoscopic sinus surgery on chronic sinusitis and the improvement of allergy and olfactory function.Methods:79 chronic sinusitis patients who received therapy from March 2017 to February 2018 were selected as research objects and divided into the observation group(n=41)and the control group(n=38)with simple random grouping method.The control group was given endoscopic sinus surgery,and the observation group was treated with medloratadine on the basis of the control group.The control group was given endoscopic sinus surgery,and the observation group was treated with medloratadine on the basis of the control group.The post-treatment comparison was made between both groups on treatment efficacy,smell,Lund-Mackay,Lund-Kennedy scores,allergy,and inflammation.Results:The post-treatment evaluation reveals that,in comparison with the control group,the total effective rate of observation group was significantly higher[92.68%(38/41)vs68.42%(26/38)](P<0.05=;smell,Lund-Mackay and Lund-Kennedy scores were significantly lower[(2.51±0.70)scores vs(4.03±0.92)scores,(4.32±0.51)scores vs(6.56±0.83)scores,(2.46±0.12)scores vs(4.03±0.26)scores](P<0.05);serum TIgE and ECP were significantly lower[(57.98±4.91)kU/L vs(63.75±7.02)kU/L,(4.02±0.50)ng/L vs(5.38±0.92)ng/L](P<0.05);serum levels of TNF-alpha,IL-6 and IL-8 were significantly lower[(1.19±0.52)ng/ml vs(2.70±0.81)ng/ml,(5.10±1.05)pg/ml vs(10.26±2.01)pg/ml,(281.96±30.49)ng/L vs(316.30±42.80)ng/L](P<0.05).Conclusion:Medloratadine combined with endoscopic sinus surgery can alleviate the clinical symptoms,improve the ventilation function of the nasal cavity and sinuses,restore the olfactory function,reduce the allergic reaction,promote the recovery,and the treatment effect is significant.
作者
李君
LI Jun(The People's Hospital of Danzhou City,Hainan Danzhou 571700,China)
出处
《河北医学》
CAS
2020年第5期731-735,共5页
Hebei Medicine
基金
海南省卫生计生行业科研项目,(编号:2017985261)。
关键词
慢性鼻窦炎
枸地氯雷他定
鼻内镜手术
变态反应
嗅觉功能
Chronic sinusitis
Diloratadine citrate
Endoscopic sinus surgery
Allergy
Olfactory function
