摘要
目的探讨血清胱抑素C(Cys-C)与趋化素对空腹血糖受损(IFG)人群亚临床动脉粥样硬化病情发生、发展的影响。方法选择2016年4月至2019年7月苏州市中医医院收治的IFG患者226例为研究对象。其中137例单纯IFG患者为对照组,89例IFG伴亚临床动脉粥样硬化患者为观察组。分析两组患者的一般临床资料、血清生化指标及趋化素水平,以及与亚临床动脉粥样硬化的关系。结果两组患者的性别比例、体质量指数(BMI),以及糖化血红蛋白(HbA1c)、清蛋白、空腹血糖(FBG)、C反应蛋白(CRP)水平比较差异均无统计学意义(P>0.05);观察组患者的年龄、收缩压、舒张压、臂踝脉搏波传导速度、三酰甘油(TG)、血清肌酐、Cys-C、趋化素、低密度脂蛋白胆固醇(LDL-C)水平均高于对照组患者,差异均有统计学意义(P<0.05);观察组患者总胆固醇(TC)、血红蛋白、高密度脂蛋白胆固醇(HDL-C)水平均低于对照组患者,差异均有统计学意义(P<0.05)。两组患者的年龄、收缩压、舒张压、臂踝脉搏波传导速度、TG、血清肌酐、Cys-C、趋化素、LDL-C水平与亚临床动脉粥样硬化呈正相关(r=0.2254、0.3041、0.3589、0.4251、0.3625、0.4756、0.9625、0.9748、0.3652,P<0.001);TC、血红蛋白、HDL-C水平与亚临床动脉粥样硬化呈负相关(r=-0.4132、-0.3659、-0.4218,P<0.001);性别、BMI,以及HbA1c、清蛋白、FBG、CRP水平与亚临床动脉粥样硬化不相关(P>0.05)。血清Cys-C和趋化素是影响IFG患者合并亚临床动脉粥样硬化的独立危险因素。结论Cys-C和趋化素水平可能与IFG亚临床动脉粥样硬化的发生、发展相关。
Objective To explore the effect of serum cystatin C(Cys-C)and chemokine levels on the occurrence and development of subclinical atherosclerosis condition in the population with impaired fasting blood glucose(IFG).Methods A total of 226 patients with IFG admitted to the Suzhou Municipal Hospital of Traditional Chinese Medicine from April 2016 to July 2019 were selected as the study subjects.Among them,137 cases of simple IFG served as the control group,and 89 cases of IFG complicating subclinical atherosclerosis served as the observation group.The general clinical data and routine serological indicators of the two groups were analyzed,and their relationship with subclinical atherosclerosis was analyzed.Results There were no statistically significant differences in the sex ratio,BMI,HbA1 c,albumin,FBG and CRP levels between the two groups;the age,systolic blood pressure,diastolic blood pressure,brachial ankle pulse wave velocity,TG,serum creatinine,Cys-C,chemokine and LDL-C levels in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05);the levels of TC,Hb and HDL-C were lower than those in the control group,the differences were statistically significant(P<0.05).The age,systolic blood pressure,diastolic blood pressure,brachial ankle pulse wave velocity,TG,serum creatinine,Cys-C,chemokine and LDL-C levels in the two groups were positively correlated with subclinical atherosclerosis(r=0.225 4,0.304 1,0.358 9,0.425 1,0.362 5,0.475 6,0.962 5,0.974 8,0.365 2,P<0.001),and negatively correlated with TC,hemoglobin and HDL-C levels(r=-0.413 2,-0.365 9,-0.421 8,P<0.001),not correlated with the gender,BMI,HbA1 c,albumin,FBG and CRP(P>0.05).Serum Cys-C and chemokine were the independent risk factors of complicating subclinical atherosclerosis in the patients with IFG.Conclusion Serum Cys-C and chemokine levels may be correlated with the occurrence and development of subclinical atherosclerosis of IFG.
作者
朱海波
李丽
ZHU Haibo;LI Li(Department of Clinical Laboratory,Suzhou Municipal Hospital of Traditional Chinese Medicine,Suzhou,Jiangsu 215001,China;Obstetrics and Gynecology Laboratory,First Affiliated Hospital of Suzhou University,Suzhou,Jiangsu 215001,China)
出处
《检验医学与临床》
CAS
2020年第10期1362-1365,共4页
Laboratory Medicine and Clinic
