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脉冲染料激光联合二氧化碳点阵激光对兔耳增生性瘢痕的影响 被引量:13

Effect of carbon dioxide fractional laser combined with pulsed dye laser on hypertrophic scar in rabbit ears
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摘要 目的:评价脉冲染料激光(PDL,585 nm)联合二氧化碳点阵激光(CO 2FL,10600 nm)对兔耳增生性瘢痕的影响。方法:对20只雌性新西兰大耳兔进行造模,每只兔耳共有8处瘢痕,其中2处为对照,2处给予脉冲染料激光、2处给予二氧化碳点阵激光、2处给予联合治疗,两周治疗1次,共治疗2次。两组于治疗14天和28天后,检测瘢痕的瘢痕增生指数(SEI)、瘢痕内成纤维细胞密度、胶原纤维面积、细胞凋亡以及TGF-β1、Smad3表达的水平变化。结果:联合治疗组SEI指数、成纤维密度指标、胶原纤维面积、TGF-β1、Smad3表达明显低于脉冲染料激光组、二氧化碳点阵激光组及对照组(均P<0.05),细胞凋亡率高于上述3组(均P<0.05)。结论:PDL联合CO 2FL激光对增生性瘢痕的干预效果优于脉冲染料激光和二氧化碳点阵激光单独治疗。 Objective:To assess the effect of carbon dioxide fractional laser(CO 2FL,10600nm),combined with pulsed dye laser(PDL,585nm)on hypertrophic scars.Methods:The hypertrophic scars model was established in 20 New Zealand rabbits.There were 8 hypertrophic scars in every ear of the rabbits,including 2 scars treated as controls,2 treated with CO 2FL,2 treated with PDL,and 2 treated with PDL combined with CO 2FL,once every 2 weeks for 2 times.The Scar Elevation Index(SEI),collagen I and collagen III,apoptotic fibroblast cells,and the TGF-β1 and Smad3 levels were detected after treated for 14 days and 28 days.Results:The SEI,fibroblast density index,collagen fiber area,and the level of TGF-β1 and Smad3 in the PDL combined with CO 2FL group were lower than those in the control group,PDL group and CO 2FL group,with significant differences(P s<0.05).The cell apoptosis rate was higher in the PDL combined with CO 2FL group than in other groups,with significant differences(P s<0.01).Conclusion:PDL combined with CO 2FL laser in the treatment of hypertrophic scar is more effective than PDL or CO 2FL laser alone.
作者 彭曦 熊维 黄海艳 邹彦芬 姜彬 刘小明 简杏玲 于波 PENG Xi;XIONG Wei;HUANG Haiyan;ZOU Yanfen;JIANG Bin;LIU Xiaoming;JIAN Xingling;YU Bo(Department of Dermatology,Peking University Shenzhen Hospital,Shenzhen 518000,China)
出处 《中国麻风皮肤病杂志》 2020年第5期262-266,共5页 China Journal of Leprosy and Skin Diseases
关键词 二氧化碳点阵激光 脉冲染料激光 增生性瘢痕 CO 2FL PDL hypertrophic scar
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  • 1胡晓旻,孙晓文,许纯孝.肿瘤坏死因子受体基因转移增强TNF杀伤肿瘤细胞作用的研究[J].医学研究生学报,2001,14(4):343-346. 被引量:5
  • 2刘晋西,岑瑛.细胞凋亡与病理性瘢痕的研究进展[J].西部医学,2004,16(4):364-366. 被引量:2
  • 3潘姝,利天增,李叶扬,陈晓东,谢举临,徐盈斌,祁少海.积雪草甙对增生性瘢痕成纤维细胞增殖与Smad7蛋白的影响[J].第三军医大学学报,2005,27(1):49-52. 被引量:20
  • 4李希军,柳大烈,王吉慧.兔耳增生性瘢痕模型建立方法的探讨[J].中国美容医学,2006,15(5):499-500. 被引量:32
  • 5Uppal RS,Khan U,Kakar S,et al. The effects of a single dose of 5-fluorouraeil on keloid scars: a clinical trial of timed wound irrigation after extralesional excision[J].Plast Reconstr Surg, 2001,108(5) : 1218.
  • 6Davison,Steven P. Ineffective Treatment of Keloids with Interferon Alpha-2b[J]. Plast Reconstr Surg, 2006,117 (1):247.
  • 7Malaker K, Vijayraghavan K, Hodson I, et al. Retrospective analysis of treatment of unresectable keloids with primary radiation over 25 years[J].Clin Oncol, 2004,16: 290.
  • 8Ragoowansi R, Cornes PG. Treatment of keloids by surgical excision and immediate postoperative single-fraction radiotherapy [J].Plast Reconstr Surg, 2003, 111 ( 6 ) : 1853.
  • 9果磊 沈为民 张恒术.Nd:YAG激光联合^90Sr射线防治病理性瘢痕疗效观察.重庆医科大学学报,2002,27(2):80-80.
  • 10De Lorenzi, Tielemans HJ. Is the Treatment of Keloid Scars Still a Challenge in 2006? [J]. Ann Plast Surg, 2007,58(2) : 186.

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