摘要
目的探讨全身放疗(TBI)联合大剂量环磷酰胺(CTX)为预处理的自体外周血造血干细胞移植(auto-HSCT)治疗T淋巴母细胞淋巴瘤(T-LBL)的效果。方法回顾性分析2015年12月至2018年4月在河南省淋巴瘤诊疗中心接受auto-HSCT治疗的7例T-LBL患者的临床特点、造血重建、移植效果、复发及花费情况。结果 7例T-LBL患者,男4例,女3例,发病中位年龄22(15~54)岁,Ⅱ期1例,Ⅲ期2例,Ⅳ期4例,合并纵隔肿物5例,合并骨髓侵犯3例。诱导治疗后7例患者均达到完全缓解(CR)。移植后造血功能均顺利重健,粒系植入中位时间11(10~13)d,巨核系植入中位时间12(11~42)d。中位随访时间33(14~51)个月,1例患者复发死亡,其余6例均无病生存。结论以TBI联合大剂量CTX为预处理的auto-HSCT治疗化疗敏感的T-LBL具有良好的潜力,移植相关死亡率低,安全性好。
Objective To discuss the effects on autologous peripheral blood stem cell transplantation(auto-HSCT) with total body irradiation(TBI) and high-dose cyclophosphamide(CTX) conditioning regimen for T lymphoblastic lymphoma(T-LBL).Methods The clinical data, hematopoietic reconstitution, transplantation effect, relapse and cost of 7 T-LBL patients received auto-HSCT in Lymphoma Diagnosis and Treatment Center of Henan Province from December 2015 to April 2018 were analyzed.Results The median age of 7 T-LBL patients(4 males and 3 females) was 22(15-54) years old. The clinical staging showed that 1 case was in stage Ⅱ, 2 cases were in stage Ⅲ and 4 cases were in stage Ⅳ. The mediastinal masses were in 5 patients and the bone marrow was involved in 3 patients. All the 7 patients were complete remission(CR) status after induction chemotherapy. All the 7 patients achieved engraftment, and the median times of neutrophil and platelet engraftment were 11(10-13) days and 12(11-42) days, respectively. After the median follow-up of 33(14-51) months, 1 patient died of relapse, and 6 patients were CR.Conclusion The auto-HSCT with TBI and high-dose CTX conditioning regimen is safe and effective for chemotherapy-sensitive T-LBL, and it has good therapeutic potential.
作者
侯户婷
陈清江
张旭东
钱思宇
胡俊霞
王欣
王泽元
尹美凤
吴少旋
董萌
丁梦杰
张明智
HOU Hu-ting;CHEN Qing-jiang;ZHANG Xu-dong;QIAN Si-yu;HU Jun-xia;WANG Xin;WANG Ze-yuan;YIN Mei-feng;WU Shao-xuan;DONG Meng;DING Meng-jie;ZHANG Ming-zhi(The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Lymphoma Diagnosis and Treatment Center of Henan Province,Zhengzhou 450052,China)
出处
《河南医学研究》
CAS
2020年第15期2707-2710,共4页
Henan Medical Research
基金
国家自然科学基金青年项目(81700187)。
关键词
T淋巴母细胞淋巴瘤
自体外周血造血干细胞移植
全身放疗
预处理
T lymphoblastic lymphoma
autologous peripheral blood stem cell transplantation
total body irradiation
conditioning regimen
