摘要
磁性粒子成像是一种具有高成像分辨率的示踪剂成像技术。针对现阶段成像系统的开放式扫描难题,利用高灵敏度的线型零磁场,实现高分辨率的二维扫描成像方法。设计一种具有开放式线圈结构的线型零磁场,利用梯度静磁场构造线型零磁场以确定示踪剂的位置,在均匀交变磁场实现线型零磁场的平移扫描。对该线圈结构进行详细的设计分析,首先确定实现高分辨率的磁性粒子成像线圈系统的电流驱动方式;接着对开放式线型零磁场的扫描方式进行有限元仿真计算分析;最后根据其驱动方式与平移扫描区域范围的关系,进行粒子质量分数模型的成像实验。实验结果表明,开放式线圈结构所构成的线型零磁场在1.316T/m的梯度磁场中,可以实现在成像区域为17mm×17mm内的磁性纳米粒子示踪剂的高分辨率成像,其分辨率可达亚毫米级,理论证明了开放式线型零磁场扫描方式用于磁性粒子成像的可行性。
Magnetic particle imaging is a tracer imaging technique with high imaging resolution. Aiming at the open scanning problem of the current imaging system, a high-resolution two-dimensional scanning imaging method is realized by a highly sensitive magnetic field-free line. A magnetic field-free line with an open coil structure is designed. The magnetic field-free line is constructed by gradient static magnetic field to determine the position of the tracer, and the uniform alternating magnetic field is used for translation scanning of magnetic field-free line. The coil structure is analyzed in detail. Firstly, the current driving method of the magnetic particle imaging coil system for realizing high resolution is determined. Then the finite element simulation calculation analysis of the open magnetic field-free line scanning method is carried out. Finally, according to the relationship between the driving mode and the range of the translation scanning region, the imaging experiment of the particle quality score model is carried out. The results show that the open coil structure of the magnetic field-free line can realize high resolution imaging of magnetic nanoparticle tracer in the imaging area of 17 mm×17 mm in a gradient magnetic field of 1.316 T/m, the resolution can reach sub-millimeter. It is proved that the magnetic field-free line scanning method is feasible for magnetic particle imaging.
作者
刘洋洋
杜强
柯丽
祖婉妮
Liu Yangyang;Du Qiang;Ke Li;Zu Wanni(School of Electrical Engineering Shenyang University of Technology,Shenyang 110870,China)
出处
《电工技术学报》
EI
CSCD
北大核心
2020年第10期2088-2097,共10页
Transactions of China Electrotechnical Society
基金
国家自然科学基金(51377109)
辽宁省自然科学基金计划(2019-ZD-0204)资助项目。
关键词
磁性粒子成像
开放式
成像分辨率
线型零磁场
有限元仿真
Magnetic particle imaging
open
imaging resolution
magnetic field-free line
finite element simulation
