摘要
[目的]探索"湿"证与幽门螺旋杆菌(HP)感染的相关性及对胃黏膜屏障中胃黏液蛋白MUCA5AC、MUC6、MUC1表达的影响。[方法]以随机数字表法将研究对象分为观察组(湿证)和对照组(健康体检人群),每组各80例,研究与HP感染的相关性,并进一步探索2组胃黏膜中MUCA5AC、MUC6、MUC1因子的表达情况。[结果]湿证组中HP阳性率明显高于对照组,2组之间差异有统计学意义(P<0.05)。湿证与HP感染呈正相关(r=0.681,P<0.01)。观察组胃黏膜中MUCA5AC、MUC6、MUC1因子表达明显低于对照组(P<0.05)。[结论]湿邪能降低胃黏膜屏障中黏液蛋白的表达,破坏胃黏膜屏障,可能是HP感染或复发的关键病理因素。
[Objective]To explore the correlation between"dampness"syndrome and Helicobacter pylori(HP)infection and the expression of MUCA5 AC,MUC6 and MUC1 in gastric mucosal barrier.[Methods]Eighty cases of patients with"dampness"syndrome as the observation group and 80 cases of people with moderate constitution as the control group were identified in the physical examination center.The correlation between the two groups of HP infection and the expression of muca5 AC,MUC6 and MUC1 in gastric mucosa were studied by random number table.[Results]The positive rate of HP in the wet syndrome group was significantly higher than that in the control group,and the difference between the two groups was statistically significant(P<0.05).Dampness syndrome was positively correlated with HP infection(r=0.681).The expression of MUCA5 AC,MUC6 and MUC1 in the gastric mucosa of the observation group was significantly lower than that in the control group(P<0.05).[Conclusion]Dampness can decrease the expression of mucin in the gastric mucosal barrier and destroy the gastric mucosal barrier,which may be the key pathological factor of HP infection or recurrence.
作者
夏文娟
邱伟
杨振斌
方晓华
陈莉丽
徐致君
XIA Wen-juan;QIU Wei;YANG Zhen-bin;FANG Xiao-hua;CHEN Li-li;XU Zhi-jun(Department of Spleen and Gastroenterology,Yangzhou Hospital of Traditional Chinese Medicine,Nanjing University of Traditional Chinese Medicine,Yangzhou 225000,China)
出处
《中国中西医结合消化杂志》
CAS
2020年第4期280-282,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
