摘要
目的分析不同病理类型胃息肉幽门螺杆菌(Hp)感染及其与黏膜组织内缺氧诱导因子-1α(HIF-1α)表达的相关性。方法选取2017年2月至2019年2月在内蒙古自治区人民医院接受治疗且经胃镜检测确诊为胃息肉的124例患者作为胃息肉组;选取同期100例慢性胃炎患者作为胃炎组。观察并记录胃息肉组患者的不同病理组织类型,胃息肉组患者不同部位、不同病理类型胃息肉的Hp感染情况,两组患者胃黏膜组织内HIF-1α蛋白与mRNA的表达量及胃息肉患者HIF-1α表达量与Hp感染的相关性。结果胃息肉组的Hp感染率低于胃炎组[48.39%(60/124)比79.00%(79/100)](P<0.05)。在不同病理类型的胃息肉中,腺瘤性息肉的Hp感染率为30.00%(3/10),炎性息肉为68.42%(13/19),胃底腺息肉为15.15%(5/33),增生性息肉为62.90%(39/62)。胃息肉组胃黏膜组织内HIF-1α蛋白与mRNA的表达量均高于胃炎组[(62.71±4.50)%比(24.19±4.38)%,(43.18±1.37)%比(4.62±1.29)%],且胃息肉组不同病理类型间HIF-1α蛋白与mRNA的表达量比较差异有统计学意义(P<0.05)。不同病理类型胃息肉患者的Hp感染率与HIF-1α的表达无相关性(r=0.055,P=0.219)。结论胃息肉的形成可能与Hp感染有关,且胃息肉患者黏膜组织内HIF-1α的表达水平升高。
Objective To analyze the gastric polyps Helicobacter pylori(Hp)infection of different pathological types and their correlations with hypoxia inducible factor-1α(HIF-1α)expression in mucosa.Methods From Feb.2017 to Feb.2019,124 patients who were treated in the Inner Mongolia Autonomous Region People′s Hospital and diagnosed as gastric polyps by gastroscopy were included as a gastric polyp group,and 100 patients with chronic gastritis during the same period were included as a gastritis group.The different pathological types of the gastric polyps group,the Hp infection of the gastric polyps patients with different locations and pathological types,the expression of HIF-1αprotein and mRNA in the gastric mucosa of both groups,and the relationship between the expression of HIF-1αand Hp infection in patients with gastric polyps were observed and recorded.Results The Hp infection rate of the gastric polyp group was lower than that of the gastritis group[48.39%(60/124)vs 79.00%(79/100)](P<0.05).In gastric polyps of different pathological types,the Hp infection rate of adenomatous polyps was 30.00%(3/10),of inflammatory polyps was 68.42%(13/19),of gastric fundus gland polyps was 15.15%(5/33),of proliferative polyps was 62.90%(39/62).The expression of HIF-1αprotein and mRNA in gastric mucosa of the gastric polyp group was significantly higher than that of the gastritis group[(62.71±4.50)%vs(24.19±4.38)%,(43.18±1.37)%vs(4.62±1.29)%],and the expression of HIF-1αprotein and mRNA in different pathological types of gastric polyp group was statistically significantly different(P<0.05).There was no significant correlation between Hp infection and HIF-1αexpression in gastric polyps of different pathological types(r=0.055,P=0.219).Conclusion The formation of gastric polyps may be associated with Hp infection,and the expression of HIF-1αin mucosal tissues of patients with gastric polyps is elevated.
作者
陈光远
刘星群
王秀艳
CHEN Guangyuan;LIU Xingqun;WANG Xiuyan(Medical Examination Division,Inner Mongolia People′s Hospital,Hohhot 010017,China)
出处
《医学综述》
2020年第10期2031-2034,2041,共5页
Medical Recapitulate
基金
内蒙古自治区自然科学基金(2017MS08157)
内蒙古自治区人民医院院内基金(2016010)。
关键词
胃息肉
幽门螺杆菌
缺氧诱导因子-1Α
Gastric polyps
Helicobacter pylori
Hypoxia-inducible factor-1α
