摘要
目的建立终末期肿瘤营养不良患者肠外营养液药学监护新模式。方法随机选取我院2018年7月—12月实施肠外营养液药学监护新模式后的终末期肿瘤营养不良患者60例为观察组,并选取2018年1月—6月新模式实施前的60例患者作为对照组,比较两组患者的营养状态及免疫功能指标。结果观察组患者血清IgA、IgM、IgG水平均显著高于对照组(P<0.05),CD3^+、CD3^+/CD4^+、CD4^+/CD8^+水平均显著高于对照组(P<0.05),TP、Hb、ALB、TSF、BMI等营养指标均显著高于对照组(P<0.05);观察组患者营养液中电解质、微量元素、维生素的不合理应用发生率均显著低于对照组(P<0.05);观察组患者不良反应总发生率显著低于对照组(P<0.05)。结论肠外营养液药学监护新模式的应用可有效提升终末期肿瘤营养不良患者的营养状况,改善其免疫功能,且安全性较好。
Objective To establish a new pharmaceutical care model of parenteral nutrition solution for patients with end-stage tumor malnutrition.Methods Sixty patients with end-stage tumor malnutrition who received new mode of parenteral nutrition solution pharmaceutical care in our hospital between July and December in 2018 were randomly selected as the observation group,and 60 patients who got treatment between January and June in 2018 before the implementation of the new mode were selected as the control group.Compare the nutritional status and immune function indexes between the two groups.Results The serum levels of IgA,IgM and IgG in observation group were significantly higher than those in control group(P<0.05),and the CD3^+level,the CD3^+/CD4^+and the CD4^+/CD8^+were significantly higher than those in control group(P<0.05).In addition,the nutritional indexes of TP,Hb,ALB,TSF and BMI were significantly higher than those in control group(P<0.05).The incidence of unreasonable application of electrolytes,trace elements and vitamins in the nutrient solution was significantly lower in the observation group than in the control group(P<0.05).The total incidence of adverse reactions was also significantly lower in the observation group than in the control group(P<0.05).Conclusion The new pharmaceutical care model of parenteral nutrition solution can effectively help to improve the nutritional status and immune function of patients with end-stage tumor malnutrition,and have better safety.
作者
于晓红
倪瑞雪
史东旭
YU Xiaohong;NI Ruixue;SHI Dongxu(Otolaryngology Department,the First Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang,150000,China;Oncology Department,the First Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang,150000,China)
出处
《肿瘤药学》
CAS
2020年第2期237-240,共4页
Anti-Tumor Pharmacy
关键词
终末期肿瘤
营养不良
肠外营养液
药学监护模式
End-stage tumor
Malnutrition
Parenteral nutrient solution
Pharmaceutical care model
