摘要
目的:观察加味寿胎丸治疗血栓前状态致复发性流产肾虚血瘀证的疗效及对凝血因子的影响。方法:100例患者随机分为对照组和观察组,各50例。分别给予补肾养血胶囊+依诺肝素钠、加味寿胎丸+依诺肝素钠,疗程均为60 d。观察两组患者血清凝血因子活化蛋白S(PS),活化蛋白C(PC),血小板聚集功能(PAF),血小板聚集率(PagT),抗凝血酶(AT),狼疮抗凝物质(LA)阳性率,抗心磷脂抗体(ACA)阳性率,纤溶酶原激活物抑制物-1(PAI-1),组织因子(TF),纤维蛋白原(Fig),纤溶酶-抗纤溶酶复合物(PAP),血酶-抗凝血酶复合物(TAT),纤维蛋白肽A(FPA),纤维蛋白原(FIB),血小板α颗粒膜糖蛋白-140(GMP-140),人凝血酶原片段(F1+2),组织型纤溶酶原活化因子(t-PA),D-二聚体(D-D),活化的部分凝血活酶时间(APTT),凝血酶原时间(PT),凝血酶时间(TT)。比较临床疗效、妊娠率、中医证候和不良反应。结果:研究期间脱落4例。观察组总有效率97.9%(48/49),高于对照组的85.1%(40/47)(χ^2=5.713,P<0.05);观察组妊娠率89.8%(44/49),高于对照组的70.2%(33/47)(χ^2=6.351,P<0.05);观察组中医证候积分低于对照组(P<0.05)。观察组PS,PC,AT,TF,Fig,FPA,APTT,TT指标高于对照组(P<0.05),PAF,PagT,LA阳性率,ACA阳性率,PAI-1,PAP,TAT,FIB,GMP-140,F1+2,t-PA,D-D,PT指标降于对照组(P<0.05)。观察组不良反应发生率10.2%(5/49),明显低于对照组的35.4%(17/48)(P<0.05)。结论:加味寿胎丸可有效改善血栓前状态致复发性流产肾虚血瘀证患者的临床症状,凝血因子指标。
Objective:To observe the efficacy of modified Shoutaiwan on recurrent abortion due to prethrombotic status with kidney deficiency and blood stasis and investigate its effect on coagulation factors.Method:The 100 cases were randomly divided into control group and observation group,50 cases in each group.Bushen Yangxue capsule+enoxaparin sodium were given in control group,while modified Shoutaiwan+enoxaparin sodium were given in observation group,with a treatment course of 60 d in both groups.The serum clotting factor activated protein S(PS),activated protein C(PC),platelet aggregation function(PAF),platelet aggregation rate(PagT),antithrombin(AT),lupus anticoagulant material positive positive predictive value(LA),anti cardiolipin antibody positive rate of positive predictive value(ACA),plasminogen activator inhibitor-1(PAI-1),tissue factor(TF),fibrinogen(Fig),fibrinogen(FIB),fibrinogen alpha granule membrane glycoprotein-140(GMP-140),fibrinogen fragment(F1+2),tissue fibrinogen activation factor(t-PA),D-dimer(D-D),activated partial thromboplastin time(APTT),prothrombin time(PT),and thrombin time(TT)were observed.Clinical efficacy,pregnancy rate,traditional Chinese medicine(TCM)syndromes and adverse reactions were compared between the two groups.Result:4 cases withdrew from the study.The total effective rate in observation group was 97.9%(48/49),higher than 85.1%(40/47)in control group(χ^2=5.713,P<0.05).The pregnancy rate in observation group was 89.8%(44/49),higher than 70.2%(33/47)in control group(χ^2=6.351,P<0.05).The score of traditional Chinese medicine syndromes in observation group was lower than that in control group.The indexes of PS,PC,AT,TF,Fig,FPA,APTT and TT in observation group were significantly higher than those in control group(P<0.05),while PAF,PagT,LA,ACA,PAI-1,PAP,TAT,FIB,GMP-140,F1+2,t-PA,D-D and PT were lower than those in control group(P<0.05).The incidence of adverse reactions in observation group was 10.2%(5/49),lower than 35.4%(17/48)in control group(P<0.05).Conclusion:Modified Shoutaiwan can effectively improve the clinical symptoms of recurrent abortion due to prethrombotic status and improve the coagulation factors in patients with kidney deficiency and blood stasis.
作者
韩春艳
孙自学
胡晓华
韩晶晶
HAN Chun-yan;SUN Zi-xue;HU Xiao-hua;HAN Jing-jing(Henan Province Hospital of Traditional Chinese Medicine,Zhengzhou 450002,China;Zhengzhou People's Hospital,Zhengzhou 450006,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2020年第10期51-56,共6页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家中医临床研究基地科研专项(2019JDZX039)
河南省中医药青苗人才培养项目(豫中医科教[2018]16号)。
关键词
加味寿胎丸
依诺肝素钠
血栓前状态
复发性流产
肾虚血瘀证
凝血因子
modified Shoutaiwan
enoxaparin sodium
prethrombotic status
recurrent abortion
kidney deficiency and blood stasis
clotting factor
