摘要
目的分析血浆糖化血红蛋白(HbA1c)与超敏C反应蛋白(hs-CRP)联合检测在糖尿病合并冠心病患者中的应用价值。方法选取于2015年2月-2019年2月间三门峡市陕州区人民医院收治的168例糖尿病患者,将84例糖尿病患者设为对照组,将84例糖尿病合并冠心病患者设为观察组,比较两组血浆HbA1c与hs-CRP水平;并根据观察组的HbA1c水平,将6.5%及以下患者设为低HbA1c组,6.5%以上患者设为高HbA1c组,比较高、低HbA1c组生化指标及冠状动脉病变状况。结果观察组HbA1c为(5.53±1.56)%,hs-CRP为(6.91±1.73)mg/L高于对照组的(4.87±1.12)%和(6.15±1.21)mg/L,差异有统计学意义(P<0.05);高HbA1c组TG为(2.52±0.69)mmol/L、TC为(5.26±1.54)mmol/L、肌酸激酶同工酶(CK-MB)为(19.43±5.47)U/L,hs-CRP为(6.68±1.95)mg/L高于低HbA1c组的(1.61±0.33)mmol/L、(4.22±1.21)mmol/L、(16.12±4.36)U/L、(5.24±1.42)mg/L,差异有统计学意义(P<0.05);高HbA1c组多支病变发生率为62.79%高于低HbA1c组的36.59%,差异有统计学意义(P<0.05)。结论 HbA1c与hs-CRP可作为诊断及预防糖尿病合并冠心病的重要指标,但HbA1c水平升高,可加剧冠状动脉病变,提高机体炎症程度。
Objective To analyze the application value of combined detection of plasma HbA1 c and hs-CRP in patients with diabetes mellitus complicated with coronary heart disease.Methods 84 diabetic patients from February, 2015 to February, 2019,in the hospital were divided into control group and 84 diabetic patients with coronary heart disease as observation group, and the plasma HbA1c and hs-CRP levels were compared between the two groups. According to the HbA1c level of the observation group,6.5% and less patients were divided into low HbA1c group and more than 6.5% patients as high HbA1c group. Biochemical indexes and coronary artery diseases were compared.Results HbA1c and hs-CRP in the observation group were(5.53±1.56)% and(6.91±1.73)mg/L, respectively, which were significantly higher than those in the control group(4.87±1.12)% and(6.15 ±1.21) mg/L. There was statistically significant difference(P<0.05). In high HbA1c group, TG was(2.52 ± 0.69) mmol/L, TC was(5.26 ± 1.54) U/L,CK-MB was(19.43±1.47) U/L, hs-CRP was(6.68±1.47)U/L, which was higher than those of(1.61 ±0.33) mmol/L,(4.22 ±1.21)mmol/L,(16.12 ±4.36) U≤L and(5.24±1.42) mg/L in low HbA1c group. There was statistically significant difference(P<0.05).The incidence of multi-vessel lesions in high HbA1c group was 62.79%, which was higher than that in low HbA1c group(36.59%,P<0.05).Conclusion HbA1c and hs-CRP can be used as important indexes in the diagnosis and prevention of diabetes mellitus complicated with coronary heart disease. The increase of HbA1c level can aggravate coronary artery disease and improve the degree of inflammation.
作者
王改改
WANG Gai-gai(Department of Laboratory,People’s Hospital of Shan Zhou District,Sanmenxia,Henan,472000,China)
出处
《黑龙江医学》
2020年第5期654-656,共3页
Heilongjiang Medical Journal
关键词
糖尿病合并冠心病
血浆糖化血红蛋白
超敏C反应蛋白
Diabetes with coronary heart disease
Plasma glycosylated hemoglobin
C-reactive protein
