摘要
极早期干预是类风湿关节炎(RA)防治的重要研究方向。基于经典论述及现代发病机制探讨RA前状态的中医病机,提出了脾虚风湿痹阻是RA前状态的基本病机,脾虚风袭,自身抗体产生;脾虚湿阻,肠道菌群失衡;脾胃虚弱,黏膜免疫紊乱。RA前状态临床特征、动物模型亦呈脾虚风湿痹阻的特点,探讨RA前状态病机有助于运用中医药对RA进行极早期干预。
Very early intervention is a significant research direction of rheumatoid arthritis(RA) prevention and treatment. Based on classical discourses and modern discuss on pathogenesis,this paper explores pathogenesis of preRA state in traditional Chinese medicine(TCM),and proposes that spleen deficiency and wind-damp blockade is the basic pathogenesis of pre-RA state. Specifically,spleen deficiency and wind attack causes autoantibody production;spleen deficiency and dampness blockade leads to intestinal flora imbalance;and deficiency of spleen and stomach results in mucosal immune disorder. Clinical features and animal models of pre-RA state are also characterized by spleen deficiency and wind-damp blockade. The discussion on the pre-RA state pathogenesis helps to use TCM to conduct very early intervention in RA.
作者
周东海
王俏
冯炯
温成平
ZHOU Donghai;WANG Qiao;FENG Jiong;WEN Chengping(School of Basic Medicine,Zhejiang Chinese Medical University,Hangzhou,310053)
出处
《中医杂志》
CSCD
北大核心
2020年第7期590-593,共4页
Journal of Traditional Chinese Medicine
基金
国家重点研发计划(2018YFC1705500)。
关键词
类风湿关节炎前状态
脾虚
风湿痹阻
风邪
pre-rheumatoid arthritis state
spleen deficiency
wind-damp blockade
wind pathogen
