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新生儿肺炎PCT和炎性因子水平表达及其意义 被引量:1

Expression levels and significance of PCT and inflammatory factors in neonatal pneumonia
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摘要 目的研究新生儿肺炎(NP)患儿血清高敏C反应蛋白(hs-CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)水平表达及其意义。方法选取2017年1月-2018年2月韶关市曲江区妇幼保健计划生育服务中心诊治的NP患儿80例,按细菌感染情况分为观察1组和观察2组,各40例。选择同期40例健康新生儿作为对照组。测定并比较三组的hs-CRP、PCT和IL-6水平。结果观察1组血清PCT、hs-CRP和IL-6水平明显高于观察2组和对照组,差异均有统计学意义(P<0.05)。观察1组血清PCT、hs-CRP和1L-6检测阳性率明显高于观察2组和对照组,差异均有统计学意义(P<0.05),且观察1组血清PCT、hs-CRP和1L-6诊断NP的敏感度均明显高于观察2组,差异均有统计学意义(P<0.05);观察组各指标特异度与观察2组比较差异无统计学意义(P>0.05)。结论血清hs-CRP、PCT、IL-6水平可作为NP患儿的辅助鉴别指标,为抗生素的合理使用和疗效提供依据。 Objective To study the expression levels and significance of serum high-sensitivity C-reactive protein(hs-CRP),procalcitonin(PCT)and interleukin-6(IL-6)in nenates with neonatal pneumonia(NP). Methods Eighty cases with NP who were diagnosed and treated in Qujiang District Maternal and Child Health and Family Planning Service Center of Shaoguan from January 2017 to February 2018 were selected and divided into observation group 1 and observation group 2 according to the condition of bacterial infection,40 cases in each group. Forty healthy newborns in the same period were selected as control group. The levels of hs-CRP,PCT and IL-6 were measured and compared among the three groups.Results The levels of serum PCT,hs-CRP and IL-6 in the observation group 1 were significantly higher than those in the observation group 2 and control group,the differences were statistically significant(P<0.05). The positive rates of serum PCT,hs-CRP and IL-6 in the observation group 1 were significantly higher than those in the observation group 2 and control group,the differences were statistically significant(P <0.05),and the sensitivity of serum PCT,hs-CRP and IL-6 in the observation group 1 were significantly higher than those in the observation group 2,the differences were statistically significant(P<0.05). There were no significant differences in each index specificity between the observation group 1 and observation group 2(P >0.05). Conclusion The levels of serum hs-CRP,PCT and IL-6 could be applied as auxiliary indexes to differentiate NP nenates,and provide evidence for the rational use and curative effect of antibiotics.
作者 邱小军 陈英 QIU Xiao-jun;CHEN Ying(Department of Laboratory,Qujiang District Maternal and Child Health and Family Planning Service Center of Shaoguan,Shaoguan Guangdong Province 512100,China)
出处 《中国城乡企业卫生》 2020年第3期31-33,共3页 Chinese Journal of Urban and Rural Enterprise Hygiene
关键词 新生儿肺炎 降钙素原 高敏C反应蛋白 白细胞介素-6 Neonatal pneumonia Procalcitonin High-sensitivity C-reactive protein Interleukin-6
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  • 1杨孜,郭艳军.早期早产的研究进展[J].实用妇产科杂志,2005,21(11):652-654. 被引量:28
  • 2Hedegaard SS,Wisborg K,Hvas AM.Diagnostic utility of biomarkers for neonatal sepsis-a systematic review[J].Infect Dis(Lond),2015,43(3):212-221.
  • 3Li P,Zhang W,Zhou X,et al.C-60 carboxyfullerene-based functionalised nanohybrids as signal-amplifying tags for the ultrasensitive electrochemical detection of procalcitonin[J].Clin Biochem,2015,48(3):156-161.
  • 4Luyt CE,Combes A,Reynaud C,et al.Usefulness of procalcitonin for the diagnosis of ventilator-associated Pneumonia[J].Intensive Care Med,2008,34(8):1434-1440.
  • 5胡亚美.诸福棠实用儿科学(上下)[M].8版.北京:人民卫生出版社,2015:541-620.
  • 6Trautner BW,Caviness AC,Gerlacher GR,et al.Prospective evaluation of the risk of serious bacterial infection in children who present to the emergency department with hyperpyrexia(temperature of106 degrees F or higher)[J].Pediatrics,2006,118(1):34-40.
  • 7Finfer S,Bellomo R, Lipman J, et al. Adult-population in- cidence of severe sepsis in Australian and New Zealand in- tensive care units[J]. Intensive Care Med, 2004,30(4) : 589-596.
  • 8Brun-Buisson C. Incidence, risk factors and outcome of se- vere sepsis and septic shock in adults multicenter pro- spective study in intensive care units[J]. JAMA, 2008, 274(12) :968-974.
  • 9Assicot M, Gendrel D, Carsin H, et al. High serum procal- citonin concentrations in patients with sepsis and infection [J]. Lancet,1993,341(8844) :515-518.
  • 10Bustos BR, Araneda CH. Procalcitonin for the diagnosis of late onset sepsis in newborns of very low birth weight [J]. Rev Chilena Infectol, 2012,29 (5) : 511-516.

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