摘要
冠状病毒可引起人类呼吸道、肠道等多系统感染.严重急性呼吸综合征冠状病毒(SARS-CoV,2003年)、人冠状病毒NL63(HCoV-NL63,2004年)以及目前的新型冠状病毒(SARS-CoV-2,2019年)均已被证实通过与黏膜的血管紧张素转换酶2(ACE2)结合感染人体.因此研究冠状病毒感染过程中ACE2的作用有助于了解冠状病毒的致病机制,为新型冠状病毒肺炎的防治提供参考.该文综述了ACE2在3种冠状病毒感染人体过程中作用的研究进展,主要涉及病毒棘突蛋白识别ACE2胞外域顶端,且有跨膜蛋白酶丝氨酸2(TMPRSS2)等因子参与其中.针对冠状病毒与ACE2结合的机制,可以从多个靶点设计防治药物.
Coronavirus can cause severe infections of human respiratory tract,intestinal and other multi-systems.Severe acute respiratory syndrome coronavirus(SARS-CoV,2003),human coronavirus NL63(HCoV-NL63,2004)and novel coronavirus(SARSCoV-2,2019)have been proved to infect humans by binding to the angiotensin-converting enzyme 2(ACE2).The investigation of the roles of ACE2 in the course of coronavirus infection is helpful to understand the pathogenic mechanism of coronavirus infection,providing references for the prevention and treatment of novel coronavirus pneumonia.In this paper,we review the research progress in the roles of ACE2 in the processes of three coronaviruses infections:the S protein of virus recognizes the tip of extracellular domain of ACE2,and the transmembrane protease serine 2(TMPRSS2)and other factors also take part in the processes.Herein,drugs can be designed from multiple targets according to the combination of ACE2 and S protein of coronavirus.
作者
郭俞利
卜敬华
GUO Yuli;BU Jinghua(Xiang'an Hospital of Xiamen University,Xiamen 361102,China;Eye Institute of Xiamen University,Xiamen 361102,China)
出处
《厦门大学学报（自然科学版）》
CAS
CSCD
北大核心
2020年第3期334-340,共7页
Journal of Xiamen University：Natural Science
基金
中央高校基本科研业务费专项(ZK1085)。
