摘要
抑郁症是一种持续性的心境障碍,有很高的终身患病率,至今还没有客观的实验室诊断方法。寻找特异的抑郁症生物标志物有助于预测疾病的发展,并可为早期预防与治疗提供支持。本文总结了近几年用于研究抑郁症生物标志物的样品前处理和检测技术,分析了各种技术的特点,并对潜在的生物标志物及其分析检测方法进行综述。
Major depressive disorder is a persistent mood disorder with a high lifelong prevalence rate,and there is no objective laboratory diagnosis till now. Identifying specific biomarkers of depression is helpful in predicting the disease progression and support early prevention and treatment. This article summarizes the sample pretreatment,detection techniques and the characteristics of various techniques used to study biomarkers of depression in recent years,and reviews the potential biomarkers and their analytical and detection methods.
作者
郑敏
冯艳茹
崔浩亮
李挥
连靠奇
ZHENG Min;FENG Yan-ru;CUI Hao-liang;LI Hui;LIAN Kao-qi(College of Public Health,Hebei Medical University,Shijiazhuang 050000,China;Hebei Insitute of Medical Equipment and Drugs Packaging Material Inspection,Shijiazhuang 050061,China;College of Chemical and Pharmaceutical Engineering,Hebei University of Science and Technology,Shijiazhuang 050018,China)
出处
《药物分析杂志》
CAS
CSCD
北大核心
2020年第3期393-400,共8页
Chinese Journal of Pharmaceutical Analysis
基金
河北省自然科学基金(H2019329002)
河北省国外智力引进项目资助(2019YX028A).
关键词
抑郁症
生物样本
标志物
样品前处理
分析技术
代谢组学
综述
major depressive disorder
biological sample
biomarkers
sample pretreatment
analysis technique
metabonomics
review
