摘要
目的探讨血清中C反应蛋白(CRP)、白细胞介素-6(IL-6)及降钙素原(PCT)水平变化在老年冠心病合并肺部感染的诊断价值以及其对预后的影响。方法选取2016年1月至2019年3月在我院收治的老年冠心病患者、老年冠心病合并肺部感染患者共300例。根据感染是否发生,将其分为肺部感染组和未感染组,同时随机抽取健康人群作为对照组。再根据预后情况,再将其分为预后良好组和预后不良组,比较各组患者血清中CRP、PCT以及IL-6水平在感染前后以及预后的变化,探究其预测和预后价值。结果肺部感染组和未感染组其CRP、PCT和IL-6水平均显著高于健康对照组,肺部感染组CRP、PCT和IL-6水平均显著高于未感染组;预后不良组其CRP、PCT和IL-6水平均显著高于预后良好组;采用ROC曲线诊断老年冠心病合并肺部感染的价值,其中CRP、PCT以及IL-6的曲线下面积分别为0.754、0.813、0.772,三者联合为0.857。结论检测老年冠心病合并肺部感染患者血清CRP、PCT和IL-6水平有助于评估患者的变化以及预后。
Objective To explore the clinic value of serum CRP,IL-6 and PCT detection in elderly patients with coronary heart disease complicated with pulmonary infection and its effect on prognosis.Methods A total of 300 elderly patients with coronary heart disease were selected from our hospital between January 2016 and March 2019.According to whether the infection occurred,the patients were divided into the pulmonary infection group and the non-infection group,and the healthy object was randomly selected as the control group.According to the prognosis,they were divided into good prognosis group and poor prognosis group.The serum levels of CRP,PCT and IL-6 in each group were compared before and after infection as well as the changes in prognosis,to explore their predictive and prognostic value.Results The levels of CRP,PCT and IL-6 were significantly higher in both the pulmonary infection group and the uninfected group than those in the healthy control group,while CRP PCT and IL-6 levels were significantly higher those in the pulmonary infection group than in the uninfected group.The CRP PCT and IL-6 in the group with poor prognosis were significantly higher than those in the group with good prognosis.The value of ROC curve in diagnosing elderly coronary heart disease with pulmonary infection,in which the area under the curve of CRP PCT and il-6 was 0.754,0.813,0.772,respectively,and the combined value of the three was 0.857.Conclusion The serum levels of CRP PCT and il-6 in elderly patients with coronary heart disease complicated with pulmonary infection can be used to effectively evaluate the changes of patients and the good prognosis.
作者
李韶华
吴才胜
龙平
温永红
严维力
Li Shaohua;Wu Caisheng;Long Ping;Wen Yonghong;Yan Weili(Emergency Internal Medicine,the Army's 73rd Army Hospital,Xiamen 361000,China;不详)
出处
《中国临床保健杂志》
CAS
2020年第3期388-391,共4页
Chinese Journal of Clinical Healthcare
关键词
冠心病
细菌感染
肺
C反应蛋白质
白介素-6
降钙素
预测
预后
Coronary disease
Bacterial infections,lung
C-reactive protein
Interleukin-6
Calcitonin
Forecasting
Prognosis
