摘要
目的:研究性腺激素释放激素激动药(GnRH-a)辅助治疗对子宫内膜异位症术后患者月经与激素水平的影响。方法:选取2017年5月-2018年9月于本院就诊的子宫内膜异位症术后患者50例,按照随机数字表法分为对照组与研究组,各25例。对照组行去氧孕烯炔雌醇治疗,研究组在对照组的基础上行GnRH-a治疗。比较两组痛经、性交痛及盆腔痛的疼痛程度、激素水平、月经恢复时间、不良反应发生情况及远期预后。结果:治疗后,两组痛经、性交痛及盆腔痛视觉模拟量表(VAS)评分均明显低于治疗前,且研究组痛经、性交痛及盆腔痛VAS评分均明显低于对照组(P<0.05)。治疗后,两组卵泡刺激素(follicle stimulating hormone,FSH)、黄体生成素(luteinizing hormone,LH)及雌二醇(estradiol,E2)水平均明显低于治疗前,且研究组FSH、LH及E2水平均明显低于对照组(P<0.05)。研究组经期及经量恢复正常时间均明显短于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。随访1年,研究组复发率明显低于对照组,而妊娠率明显高于对照组(P<0.05)。结论:GnRH-a辅助治疗可显著缓解子宫内膜异位症术后患者疼痛程度,降低激素水平,促使月经恢复,安全性较高,改善患者远期预后,值得临床推广。
Objective:To study the effect of gonadotropin-releasing hormone agonist (GnRH-a) adjuvant therapy on menstruation and hormone levels in patients with endometriosis after surgery.Method:A total of 50 patients with endometriosis after surgery admitted to our hospital from May 2017 to September 2018 were selected.According to the random number table method,they were divided into control group and research group,25 cases in each group.The control group was treated with Desogestrel,and the research group was treated with GnRH-a on the basis of the control group.The pain degree of dysmenorrhea,dyspareunia and pelvic pain,hormone level,menstrual recovery time,adverse reactions and long-term prognosis in the two groups were compared.Result:After treatment,the visual analogue scale (VAS) scores of dysmenorrhea,dyspareunia and pelvic pain in the two groups were significantly lower than those before treatment,and the VAS scores of dysmenorrhea,dyspareunia and pelvic pain in the research group were significantly lower than those in the control group (P<0.05).After treatment,the levels of follicle stimulating hormone (FSH),luteinizing hormone (LH) and estradiol (E2) in the two groups were significantly lower than those before treatment,and the levels of FSH,LH and E2 in the research group were significantly lower than those in the control group (P<0.05).The recovery time of menstrual period and volume in the research group were significantly shorter than those in the control group (P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05).After 1 year follow-up,the recurrence rate of the research group was significantly lower than that of the control group,while the pregnancy rate was significantly higher than that of the control group (P<0.05).Conclusion:GnRH-a adjuvant therapy can significantly relieve pain degree in patients with endometriosis after surgery,reduce hormone levels,promote menstrual recovery,improve long-term prognosis,which is worthy of clinical promotion.
作者
李燕
陈海英
LI Yan;CHEN Haiying(Wuchuan People’s Hospital,Wuchuan 524500,China;不详)
出处
《中国医学创新》
CAS
2020年第11期65-68,共4页
Medical Innovation of China
