摘要
目的:观察糖肾平治疗糖尿病肾病Ⅲ~Ⅳ期患者临床疗效。方法:收集糖尿病肾病Ⅲ~Ⅳ期患者(气阴两虚、瘀血阻络型)30例,予糖肾平治疗12个月,观察治疗前后中医证候积分及血清肌酐、血尿素氮、24h尿蛋白定量、血糖(空腹及餐后2h)、糖化血红蛋白、终点事件、不良反应并予以分析,评估其肾功能及临床改善情况。结果:30例患者治疗12个月后中医证候积分、血肌酐、尿素氮、24h尿蛋白定量、空腹血糖、餐后2h血糖、糖化血红蛋白均较治疗前显著改善(P<0.05),总有效率93.33%,且无不良反应和终点事件发生。结论:糖肾平可明显改善糖尿病肾病Ⅲ~Ⅳ期患者(气阴两虚、瘀血阻络型)的肾功能,降低血糖水平,缓解临床症状,延缓糖尿病肾病进程。
Objective:To observe the clinical efficacy of Tangshenping in the treatment of patients with stageⅢ~Ⅳdiabetic nephropathy.Methods:Thirty patients with stageⅢ~Ⅳdiabetic nephropathy(syndrome of deficiency of both qi and yin,syndrome of static blood blocking collaterals)were treated with Tangshenping for 12 months.TCM syndrome scores,serum creatinine,blood urea nitrogen,24-hour urine protein blood glucose(fasting and 2 hours after meal),glycosylated hemoglobin,end point events and adverse reactions before and after treatment were observed and analyzed to evaluate the renal function and clinical improvement.Results:After treatment for 12 months,30 patients’TCM syndrome scores,serum creatinine,urea nitrogen,24-hour urine protein quantitation,fasting blood glucose,2-hour postprandial blood glucose and glycosylated hemoglobin were improved(P<0.05).Total effective rate was 93.33%.No adverse reactions and endpoint events occurred.Conclusion:Tangshenping treatment of patients with stageⅢ~Ⅳdiabetic nephropathy(syndrome of deficiency of both qi and yin,syndrome of static blood blocking collaterals)can significantly improve renal function,lower blood sugar levels,relieve clinical symptoms,and delay the progression of diabetic nephropathy.
作者
李晓洁
赵宗江
LI Xiao-jie;ZHAO Zong-jiang(Cuigezhuang Community Health Service Center,Chaoyang District,Beijing 100103,China;Beijing University of Chinese Medicine,Beijing 100029,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2020年第4期2140-2142,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
北京市朝阳区中医药专家下基层暨学术经验继承工程(No.2013-368)。
关键词
糖肾平
糖尿病肾病
肾痿
Tangshenping
Diabetic nephropathy
Kidney flaccidity