摘要
目的观察五虫通络胶囊防治颈动脉支架术后再狭窄的临床效果。方法选取济宁医学院附属日照市中医医院2015年6月-2017年6月收治的80例接受颈动脉支架植入术病人,采取随机数字表法分为对照组与观察组,每组40例,对照组口服大剂量的阿司匹林及氯吡格雷治疗,观察组在对照组基础上加用五虫通络胶囊治疗,两组病人均连续治疗6个月。比较两组治疗前后血液流变学指标变化、并发症发生率、颈动脉彩超及支架后再狭窄的发生情况,同时随访6个月观察病人的复发率及死亡率。结果两组治疗后300/s全血黏度、100/s全血黏度、血浆黏度、红细胞聚集指数、红细胞比容、纤维蛋白原均较治疗前明显降低,红细胞沉降率较治疗前明显升高,且观察组治疗后血液流变学指标改善明显优于对照组,差异均有统计学意义(P<0.05)。两组治疗后颅内出血、消化道出血、皮下淤斑及牙龈出血发生率比较差异无统计学意义(P>0.05)。两组治疗后颈动脉彩超平均血流速度(Vm)、搏动指数(PI)及收缩期血流速度(Vs)比较差异无统计学意义(P>0.05)。观察组血管狭窄发生率低于对照组(P<0.05)。两组随访期间复发率及死亡率比较差异无统计学意义(P>0.05)。结论在常规治疗的基础上加用五虫通络胶囊应用于颈动脉支架植入术后病人,能够有效预防颈动脉狭窄,改善血液流变学指标,且未增加并发症发生率。
Objective To investigate the effect of Five Worm Tongluo Capsule in the prevention and treatment of restenosis after carotid artery stenting.Methods Eighty patients underwent carotid artery stent implantation were randomly divided into two groups:the patients in control group(n=40)were treated with high-dose oral aspirin and clopidogrel therapy,and the patients in observation group(n=40)were treated with Five Worm Tongluo Capsule in the basis of control group,both groups treated for 6 months.The blood rheological index,complications rate,stent restenosis were observed.The recurrence rate and mortality were follow up for 6 months.Results Compared with data before treatment,the 300/s whole blood viscosity,100/s whole blood viscosity,plasma viscosity,erythrocyte aggregation index,erythrocyte pressure product,fibrinogen were lower,blood sedimentation was higher after treatment in two groups.The improvement of hemodynamic indexes in observation group was more significant,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of intracranial hemorrhage,gastrointestinal bleeding,subcutaneous stasis,and gingival bleeding after treatment in two groups(P>0.05).After treatment,there was no significant difference in Vm,PI,and Vs of carotid artery color ultrasound between two groups(P>0.05).Compared with the control group,the incidence of vascular stenosis was lower,and the difference was statistically significant(P<0.05).There was no significant difference in recurrence and mortality between two groups(P>0.05).Conclusion Conventional treatment combined with Five Worm Capsule in the prevention and treatment of restenosis after carotid artery stenting can effectively prevent the carotid artery stenosis,improve hemodynamics indexes,but did not increase the incidence of complications.
作者
牟磊
徐东成
秦文玲
张孟
李姗姗
刘相静
薛叶潇
李茂绪
张宪忠
丁伟
MOU Lei;XU Dongcheng;QIN Wenling;ZHANG Meng;LI Shanshan;LIU Xiangjing;XUE Yexiao;LI Maoxu;ZHANG Xianzhong;DING Wei(Rizhao Hospital of Traditional Chinese Medicine Affiliated to Jining Medical University,Rizhao 276800,Shandong,China)
出处
《中西医结合心脑血管病杂志》
2020年第9期1371-1374,共4页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金
山东省中医药科技发展计划项目(No.2017-442)
济宁医学院教师科研扶持基金项目(No.JYFC2018FKJ145)。
关键词
颈动脉支架
术后再狭窄
五虫通络胶囊
血液流变学
颈动脉彩超
carotid artery stenosis
postoperative stenosis
Five Worm Tongluo capsule
hemodynamics
carotid color ultrasonography
