摘要
目的分析中药自拟方结合高频重复经颅磁刺激治疗脑梗塞急性期后的抑郁焦虑状态。方法随机选取2017年8月—2019年8月该院脑梗塞亚急性期及恢复期患者60例,随机分为中药自拟方结合高频重复经颅磁刺激治疗组(n=30)和高频重复经颅磁刺激参照组(n=30)2组,统计分析2组患者的CT灌注脑血流量、HAMD评分、HAMA评分、CSS评分、MBI评分。结果治疗组患者治疗后的CBV、CBF、TTP、MTT分别为(3.16±1.42)mL/100 g、(55.1±9.1)mL/(100 g·min)、(4.5±2.5)s、(3.6±1.1)s,参照组患者治疗后的CBV、CBF、TTP、MTT分别为(2.71±0.82)mL/100 g、(45.9±7.4)mL/(100 g·min)、(12.2±2.4)s、(4.2±1.0)s。2组患者治疗后的CT灌注脑血流量较治疗前明显增加(P<0.05);治疗组CT灌注脑血流量增加幅度显著高于参照组(P<0.05)。治疗组患者治疗后的HAMD评分、HAMA评分、CSS评分、MBI评分分别为(11.1±2.8)分、(10.8±1.2)分、(16.7±3.1)分、(54.7±6.3)分,参照组患者治疗后的HAMD评分、HAMA评分、CSS评分、MBI评分分别为(14.1±2.7)分、(14.4±2.3)分、(19.3±3.4)分、(41.7±6.3)分。2组患者治疗后的HAMD评分、HAMA评分、CSS评分均显著低于治疗前(P<0.05),MBI评分均显著高于治疗前(P<0.05),治疗组的HAMD评分、HAMA评分、CSS评分降低幅度显著高于参照组(P<0.05),MBI评分升高幅度显著高于参照组(P<0.05)。结论中药自拟方结合高频重复经颅磁刺激治疗急性期后患者能改善患者的脑血流量,更能有效改善患者的抑郁焦虑状态。
Objective To analyze the state of depression and anxiety after acute cerebral infarction treated by Chinese herbal medicine combined with high-frequency repeated transcranial magnetic stimulation.Methods Randomly selected from August 2017 to August 2019 from 60 patients with subacute phase of cerebral infarction and recovery,were randomly divided into Chinese medicine from party combined with high frequency repetitive transcranial magnetic stimulation treatment group(n=30)and high frequency repetitive transcranial magnetic stimulation control group(n=30),the statistical analysis of two groups of CT perfusion in patients with cerebral blood flow,HAMD scores and HAMA scores,CSS score,MBI scores.Results After treatment,CBV,CBF,TTP and MTT were(3.16±1.42)mL/100 g,(55.1±9.1)mL/(100 g·min),(4.5±2.5)s,(3.6±1.1)s respectively in treatment group combined with high frequency repetitive transcranial magnetic stimulation group.After treatment,CBV,CBF,TTP and MTT in the reference group were(2.71±0.82)mL/100 g,(45.9±7.4)mL/(100 g·min),(12.2±2.4)s,(4.2±1.0)s,respectively.CT perfusion cerebral blood flow was significantly increased in the 2 groups after treatment compared with that before treatment(P<0.05).The increase of cerebral blood flow in CT perfusion in the treatment group was significantly higher than that in the control group(P<0.05).The HAMD score,HAMA score,CSS score and MBI score of the Chinese medicine self-made prescription combined with treatment group after treatment were(11.1±2.8)points,(10.8±1.2)points,(16.7±3.1)points,(54.7±6.3)points.The HAMD score,HAMA score,CSS score and MBI score of the reference group after treatment were(14.1±2.7)points,(14.4±2.3)points,(19.3±3.4)points,(41.7±6.3)points,respectively.HAMD score,HAMA score and CSS score of the two groups after treatment were significantly lower than that before treatment(P<0.05),while MBI score was significantly higher than that before treatment(P<0.05),HAMD score,HAMA score and CSS score of the treatment group were significantly lower than that of the control group(P<0.05),and MBI score was significantly higher than that of the control group(P<0.05).Conclusion The self-designed Chinese medicine prescription combined with high-frequency repeated transcranial magnetic stimulation can improve cerebral blood flow and depression and anxiety in patients after acute phase.
作者
谌德雄
SHEN De-xiong(Yangtze River Shipping General Hospital·Wuhan Brain Hospital,Wuhan,Hubei Province,430010 China)
出处
《世界复合医学》
2020年第3期58-60,共3页
World Journal of Complex Medicine
基金
武汉市卫生计生委科研项目:自拟方结合重复经颅磁刺激对于脑梗塞患者脑血流的改变及日常生活能力的影响(WZ17Z16)。
关键词
CT灌注脑血流量
中药自拟方
脑梗塞急性期后
抑郁焦虑状态
CT perfusion cerebral blood flow
Self-made prescription of traditional Chinese medicine
After acute cerebral infarction
Depressive anxiety state
