摘要
T细胞受体是T细胞激活进入免疫反应的关键因素之一,测序技术的飞快发展使我们能更快更准确地评估T细胞受体库。免疫治疗是肿瘤治疗的重大突破,T细胞受体的多样性、异质性与肿瘤免疫治疗密切相关,同时其在不同肿瘤中研究的侧重点不同。本文重点介绍了T细胞受体的多样性和异质性以及T细胞受体库与常见肿瘤免疫治疗之间的关系。
T cell receptors are one of the key factors in T cell activation into the immune response,and the rapid development of sequencing technology allows us to evaluate the T cell receptor more quickly and accurately.Immunotherapy is a major breakthrough in tumor therapy.The diversity and heterogeneity of T cell receptors are closely related to tumor immunotherapy and their research focuse differently in different tumors.This article will highlight the diversity and heterogeneity of T cell receptors and the relationship between T cell receptors repertoire and common tumor immunotherapy.
作者
王娟娟
张锴
刘莉
WANG Juan-Juan;ZHANG Kai;LIU Li(Cancer Center,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430023,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2020年第9期1140-1144,共5页
Chinese Journal of Immunology
基金
国家重点研发计划(2016YFC13038)
国家自然科学基金(81773056)资助。
关键词
T细胞受体
异质性
肿瘤
免疫治疗
T cell receptor
Heterogeneity
Tumor
Immunotherapy
