摘要
目的探究重症有机磷农药中毒(SAOPP)并呼吸衰竭应用不同剂量长托宁治疗的疗效。方法该研究涉及对象为SAOPP并呼吸衰竭患者100例,研究时间为2015年7月—2017年6月,分为常规组与干预组,每组各50例,给予常规组大剂量长托宁治疗,给予干预组小剂量长托宁维持治疗。回顾分析两组患者临床资料,对比两组患者的治疗效果、治疗情况、胆碱酯酶活性与并发症,使用统计学进行分析。结果干预组治愈率92.00%高于常规组76.00%(χ^2=4.762,P<0.05)。干预组昏迷时间为(9.21±1.57)h,住院时间为(8.92±2.35)d;常规组昏迷时间为(9.69±2.97)h,住院时间为(12.76±2.87)d,干预组患者昏迷时间、住院时间均优于常规组(t=3.485,7.320,P<0.05)。干预组治疗后1、2、3 d的胆碱酯酶活性(1.34±0.26)、(1.68±0.32)(2.92±0.55)均优于常规组(0.98±0.19)、(1.18±0.31)(1.66±0.57)(t=7.905,7.935,11.248,P<0.05)。干预组重要脏器损害、中间综合征、反跳发生率均优于常规组(P<0.05)。结论对SAOPP并呼吸衰竭患者实施小剂量长托宁维持治疗,有效提高治愈率,缩短治疗时间,促进胆碱酯酶活性恢复,降低并发症,治疗效果显著,值得临床推广及使用。
Objective To investigate the efficacy of severe organophosphorus pesticide poisoning(SAOPP)and respiratory failure with different doses of changtonin.Methods This study involved 100 patients with SAOPP and respiratory failure.The study period was from July 2015 to June 2017.They were divided into a conventional group and an intervention group,with 50 patients in each group.In the intervention group,a small dose of long-tonin maintenance treatment was given.The clinical data of two groups of patients were retrospectively analyzed,and the treatment effects,treatment conditions,cholinesterase activity and complications of the two groups of patients were compared,and statistics were used for analysis.Results The cure rate in the intervention group was 92.00%higher than that in the conventional group(76.00%)(χ^2=4.762,P<0.05).The coma time in the intervention group was(9.21±1.57)h,and the hospital stay was(8.92±2.35)d.The coma time in the conventional group was(9.69±2.97)h,and the hospital stay was(12.76±2.87)d.The length of hospital stay was better than that of the conventional group(t=3.485,7.320,P<0.05).The cholinesterase activity(1.34±0.26),(1.68±0.32)(2.92±0.55)of the intervention group at 1 d,2 d,and 3 d were better than those of the conventional group(0.98±0.19)and(1.18±0.31),(1.66±0.57)(t=7.905,7.936,11.248;P<0.05).The incidence of important organ damage,intermediate syndrome,and rebound in the intervention group were better than those in the conventional group(P<0.05).Conclusion The low-dose longtonin maintenance treatment for patients with SAOPP and respiratory failure can effectively improve the cure rate,shorten the treatment time,promote the recovery of cholinesterase activity,reduce complications,and have significant treatment effects.It is worthy of clinical promotion and use.
作者
田忠秋
TIAN Zhong-qiu(Department of Critical Care Medicine,Yutai People's Hospital,Jining,Shandong Province,272300 China)
出处
《系统医学》
2020年第7期52-54,共3页
Systems Medicine
关键词
血液灌流
小剂量长托宁维持治疗
有机磷农药中毒
呼吸衰竭
Hemoperfusion
Low-dose longtonin maintenance treatment
Organophosphorus pesticide poisoning
Respiratory failure
