摘要
目的探讨尿白蛋白肌酐比值(ACR)及中性粒细胞淋巴细胞比值(NLR)与老年2型糖尿病肾病(DN)的关系。方法以该院2017年2月至2018年2月收治的老年2型DN患者50例为观察对象,另选同期收治的50例单纯2型糖尿病老年患者为对照组。分别比较两组性别、年龄及体重指数(BMI)等基本资料,比较各项实验室生化指标水平,并作多因素的Logistic回归分析。结果单纯2型糖尿病组与2型DN组在性别、年龄及BMI对比差异无统计学意义(P>0.05)。2型DN组患者的肌酐、尿白蛋白排泄率、尿素氮、尿ACR及NLR水平明显高于单纯2型糖尿病组(均P<0.05)。经多因素Logistic回归分析,尿ACR、NLR水平的升高均是老年2型DN的独立危险因素。结论老年2型DN患者的尿ACR、NLR水平存在明显的高表达,尿ACR、NLR水平的升高会增加2型DN的发病风险。
【Objective】To investigate and analyze the relationship between urinary albumin creatinine ratio(ACR),neutrophil lymphocyte ratio(NLR)and type 2 diabetic nephropathy(DN)in the elderly.【Methods】Fifty elderly patients with type 2 DN admitted to our hospital from February 2017 to February 2018 were observed.Another 50 elderly patients with type 2 diabetes mellitus admitted in the same period were selected as the control group.The basic data of sex,age,body mass index(BMI),biochemical indexes in laboratories were compared between the two groups,and logistic regression analysis of multiple factors was made.【Results】There was no significant difference in gender,age and BMI between type 2 diabetes mellitus group and type 2 DN group(P>0.05).The levels of creatinine,urinary albumin excretion rate,urea nitrogen,urinary ACR and NLR in type 2 DN group were significantly higher than those in type 2 diabetes group(all P<0.05).Multivariate logistic regression analysis showed that increased urinary ACR and NLR levels were independent risk factors for type 2 DN in the elderly.【Conclusion】The levels of urinary ACR and NLR in elderly patients with type 2 diabetic nephropathy are significantly higher,the increased levels of urinary ACR and NLR will increase the risk of type 2 diabetic nephropathy.
作者
李静军
周林
耿秀琴
LI Jingjun;ZHOU Lin;GENG Xiuqin(Endocrine Department,Xinxiang Central Hospital,Xinxiang,Henan 453000,China)
出处
《中国医学工程》
2019年第8期21-24,共4页
China Medical Engineering
