摘要
目的:探究小剂量左甲状腺激素联合丙硫氧嘧啶治疗妊娠期甲亢疗效及安全性。方法:以2017年1月~2019年8月为研究时段,选择本院收治的妊娠期甲亢患者,共68例,将其随机编号,采取抽签法分对照组和试验组,各34例,前者给予常规剂量左甲状腺激素联合丙硫氧嘧啶治疗,后者给予小剂量左甲状腺激素联合丙硫氧嘧啶治疗,比较两组患者治疗后甲状腺功能指标(游离三碘甲状原氨酸FT3、游离甲状腺素FT4、促甲状腺素TSH)及妊娠结局。结果:试验组FT3、FT4治疗后低于对照组,TSH高于对照组,P<0.05;试验组剖宫产率、早产率、新生儿窒息率、新生儿甲亢率均低于对照组,P<0.05。结论:针对妊娠期甲亢患者,小剂量左甲状腺激素联合丙硫氧嘧啶治疗效果理想,且安全性更高,值得推荐。
Objective:To explore the efficacy and safety of low-dose thyroid hormone combined with propylthiouracil in treating hyperthyroidism during pregnancy.Methods:From January 2017 to August 2019 as the study period,a total of 68 patients with hyperthyroidism during pregnancy who were admitted to our hospital were selected.They were randomly numbered and divided into a control group and a test group,with 34 cases each.The conventional dose of levothyroxine combined with propylthiouracil was given,and the latter was given a small dose of levothyroxine combined with propylthiouracil.The efficacy and safety were compared.Results:The total clinical effective rate of the experimental group was 94.29%,which was higher than the control group by 77.14%,P<0.05;the adverse reaction rate of the experimental group was 2.94%,which was lower than the control group by 17.64%,P<0.05.Conclusion:For patients with hyperthyroidism during pregnancy,low-dose thyroid hormone combined with propylthiouracil is ideally effective and safer.It is worth recommending.
作者
陈月英
谢咏梅
李静
CHEN Yue-ying;XIE Yong-mei;LI Jing(Department of Endocrinology,Southern Theater Air Force Hospital,Guangzhou Guangdong 51000,China)
出处
《医学食疗与健康》
2020年第9期76-76,78,共2页
Medical Diet and Health
关键词
丙硫氧嘧啶
左甲状腺激素
小剂量
妊娠期甲亢
Propylthiouracil
Left Thyroid Hormone
Low Dose
Hyperthyroidism During Pregnancy
