摘要
目的探讨妊娠期甲状腺功能减退症(甲减)的流行病学特征,并分析其影响因素。方法回顾性选取河北省定州市人民医院2017年12月~2018年12月收治的1000例妊娠期妇女的临床资料,对妊娠甲减的患病率进行筛查,采用单因素及多因素logistic回归分析妊娠期甲减的影响因素。结果本研究中所纳入的妊娠期妇女1000例中,392例发生甲减,患病率为39.20%,其中127例患临床甲减,占比32.40%;265例患亚临床甲减,占比67.60%。单因素分析结果显示:年龄≥30岁、妊娠次数≥2次、文化程度专科以下、产次≥3次、有自然流产史、有糖尿病、有妊娠期高血压疾病、低碘摄入量、甲状腺过氧化物酶抗体阳性、生育间隔≥48个月的妊娠期甲减发生率较高(P<0.05);多因素logistic回归分析显示,年龄≥30岁、妊娠次数≥2次、文化程度专科以下、产次≥3次、有自然流产史、有糖尿病、有妊娠期高血压疾病、低碘摄入量、生育间隔≥48个月均是妊娠期甲减发生的独立危险因素(P<0.05)。结论甲减在妊娠期妇女中具有较高的患病率,临床上应早筛查发现并给予高度重视;并针对其影响因素制订科学预防措施以减少疾病的发生。
Objective To explore the epidemiological characteristics of hypothyroidism in pregnancy,and to analyze its influencing factors.Methods The clinical data of 1000 pregnant women who were admitted to Dingzhou People′s Hospital in Hebei Province from December 2017 to December 2018 were retrospectively selected.The prevalence of hypothyroidism in pregnancy was screened.Univariate and multivariate logistic regression were used to analyze the influencing factors of hypothyroidism in pregnancy.Results Of the 1000 pregnant women included in this study,392 pregnant women had hypothyroidism,the prevalence rate was 39.20%.Among them,127 pregnant women had clinical hypothyroidism,accounting for 32.40%,265 pregnant women had subclinical hypothyroidism,accounting for 67.60%.Univariate analysis showed that the incidence of hypothyroidism in pregnancy with age≥30 years,number of pregnancies≥2 times,education below junior college,parity≥3 times,history of spontaneous abortion,diabetes mellitus,hypertensive disorder of pregnancy,low iodine intake,thyroid peroxidase antibody positive,birth interval≥48 months were higher(P<0.05).Multivariate logistic regression analysis showed that age≥30 years,number of pregnancies≥2 times,education below junior college,parity≥3 times,history of spontaneous abortion,diabetes mellitus,hypertensive disorder of pregnancy,low iodine intake,birth interval≥48 months were independent risk factors for hypothyroidism in pregnancy(P<0.05).Conclusion Hypothyroidism has a high prevalence rate in pregnant women,which should be detected early and given high attention clinically.They can make scientific preventive measures to reduce the occurrence of disease according to its influencing factors.
作者
蔡乐男
王盼
徐月清
CAI Le′nan;WANG Pan;XU Yueqing(Department of Nursing,College of Nursing,Hebei University,Hebei Province,Baoding071000,China;Department of Pediatrics,Dingzhou People′s Hospital,Hebei Province,Dingzhou073000,China;Department of Oncology,Dingzhou People′s Hospital,Hebei Province,Dingzhou073000,China)
出处
《中国医药导报》
CAS
2020年第15期108-111,共4页
China Medical Herald
基金
河北省医学科学研究重点课题计划项目(20181778)。
关键词
妊娠期甲状腺功能减退症
流行病学
调查研究
影响因素
妊娠期高血压疾病
Hypothyroidism in pregnancy
Epidemiology
Investigation study
Influencing factors
Hypertensive disorder of pregnancy
