摘要
本课题采用分散聚合法对抗肿瘤药物进行了原位包覆,研究了其合成工艺以及聚合的机理,并探究了分散剂和反应介质对微球的粒径、粒度分布和包药率的影响。实验结果表明:当无水乙醇取40 g,蒸馏水取60 g所组成的反应介质时,能够制得理想粒径的的聚合物微球,且聚合物微球的粒度分布较为均匀。当单体质量为15 g时,取分散剂3 g可得到理想粒径的微球。当分散剂占单体质量15%~20%时,会取得较高的包覆率。单体聚合的转化率随着引发剂用量的增加而增加,且单体聚合的"高发期"在反应开始后1 h内。
In this topic,the anti-tumor drug was coated in situ by the method of dispersion polymerization,the synthesis process and the mechanism of polymerization were studied,and the effects of dispersant and reaction medium on the particle size,particle size distribution and drug coating rate of the microspheres were explored.The experimental results showed that when 40 g of anhydrous ethanol and 60 g of distilled water were used as the reaction medium,polymer microspheres with ideal particle size could be prepared,and the particle size distribution of the polymer microspheres was relatively uniform.When the monomer mass was 15 g,3 g of dispersant was taken to obtain microspheres of ideal particle size.Higher envelope rates were achieved when the dispersant was 15% to 20% of the monomer mass.The conversion rate of monomer polymerization increasesd with increasing initiator dosage and the "high incidence" of monomer polymerization was within 1 h after the start of the reaction.
作者
豆鹏飞
Dou Pengfei(Changqing Oilfield Company,Yulin 718100,Shaanxi,China)
出处
《橡塑技术与装备》
CAS
2020年第10期17-23,共7页
China Rubber/Plastics Technology and Equipment
关键词
分散聚合法
原位包覆
粒度分布
聚合物微球
聚合转化率
dispersion polymerization method
in-situ coating
particle size distribution
polymer microsphere
polymerization conversion rate
