摘要
目的探究血清甲状腺素和免疫炎症因子与青年急性缺血性脑卒中患者卒中严重程度的相关性。方法选取2017年1月30日-2018年12月30日于中山市人民医院就诊的青年急性缺血性脑卒中患者120例。根据美国国立卫生研究院卒中量表(NIHSS)将患者分为轻度脑卒中组(NIHSS≤8分)和重度脑卒中组(NIHSS>8分)。分析血清曱状腺素和免疫炎症因子在轻度脑卒中组、重度脑卒中组差异,并分析卒中严重程度的影响因素。结果轻度脑卒中患者78例,重度脑卒中患者42例。轻度及重度脑卒中患者在白细胞、纤维蛋白原水平、白球比、游离三碘曱腺原氨酸(FT3)、超敏C-反应蛋白、白细胞介素-6(IL-6)、IL-33方面比较,差异有统计学意义(P<0.05)。多因素分析结果显示,白蛋白/球蛋白(P=0.015,OR:1.738,95%CI:1.154~6.352)、FT3(P=0.044,OR:1.110,95%CI:1.039-3.147)、超敏C-反应蛋白(P=0.030,OR:1.541,95%CI:1.184~4.915)、IL-6(P=0.020,OR:1.646,95%CI:1.216~5.863)、IL-33(P=0.005,OR:2.301,95%CI:1.659~8.315)是青年急性脑卒中严重程度影响因素。NIHSS评分与白细胞水平、超敏C-反应蛋白、IL-6、IL-33呈正相关,与FT3、白球比呈负相关(P<0.05)。结论青年急性缺血性脑卒中严重程度与白球比、FT3、超敏C-反应蛋白、IL-6、IL-33相关。
Objective To investigate the correlation between serum thyroxine and immune inflammatory factors and stroke severity in young patients with acute ischemic stroke.Methods A total of 120 young patients with acute ischemic stroke(aged 18-45 years)who were admitted to our hospital from January 30,2017 to December 30,2018 were enrolled.The patients were divided into the mild stroke group(NIHSS≤8 points)and the severe stroke group(NIHSS>8 points)according to NIHSS.The differences of serum thyroxine and immune inflammatory factors in the mild stroke group and severe stroke group were analyzed,and the influencing factors of stroke severity were analyzed.Results There were 78 patients with mild stroke and 42 patients with severe stroke.There were significant differences in white blood cells,fibrinogen levels,white ball ratio,FT3,high-sensitivity C-reactive protein,IL-6,IL-33 between mild and severe stroke patients(P<0.05).Multivariate analysis showed that albumin/globulin(P=0.015,OR:1.738,95%Cl:1.154-6.352),FT3(P=0.044;OR:1.110,95%Cl:1.039-3.147),hypersensitivity C-reactive protein(P=0.030,OR:1.541,95%Cl:1.184-4.915),IL-6(P=0.020,OR:1.646,95%CI:1.216-5.863),IL-33(P=0.005,OR:2.301,95%Cl:1.659-8.315)were factors influencing the severity of acute stroke in young people.The NIHSS score was positively correlated with leukocyte level,high-sensitivity C-reactive protein,IL-6 and IL-33,and negatively correlated with FT3 and white sphere ratio(P<0.05).Conclusion The severity of acute ischemic stroke in young people are related to white ball ratio,FT3,high-sensitivity C-reactive protein,IL-6 and IL-33.
作者
梁群娣
吴文军
梁韵
LIANG Qundi;WU Wenjun;LIANG Yun(Department of Neurology,Zhongshan Peopled Hospital,Guangdong Province 528400)
出处
《中国急救复苏与灾害医学杂志》
2020年第5期547-549,565,共4页
China Journal of Emergency Resuscitation and Disaster Medicine
