摘要
目的:探讨茵陈四苓散加减调节慢性乙肝患者肠道功能及其对患者肠道菌群影响的作用机制。方法:选取慢性乙肝患者96例,根据纳入顺序,按照单双号将其均分为观察组和对照组各48例。两组患者采用同样的基础治疗,观察组联合茵陈四苓散加减,10d为1个疗程,连续治疗3个疗程。观察和比较治疗前(T0)、治疗3个疗程结束时(T1)两组患者中医证候和谷丙转氨酶(ALT)、乙肝病毒(HBV)血清标志物水平、肠道屏障功能[二胺氧化酶(DAO)、D-乳酸]、肠道菌群状况(如双歧杆菌、乳酸杆菌和大肠杆菌数量、双歧杆菌/大肠杆菌比值)。结果:观察组治疗总有效率为91.67%,高于对照组的72.92%(P<0.05)。两组患者T1时各项中医证候评分和DAO、D-乳酸水平均较T0时下降(P<0.05);T1时,观察组中医证候评分和DAO、D-乳酸水平均低于对照组(P<0.05)。两组患者T1时双歧杆菌、乳酸杆菌数量及双歧杆菌/大肠杆菌比值均较T0升高,大肠杆菌数量有所下降;与观察组比较,差异有统计学意义(P<0.05);且T1时,观察组双歧杆菌、乳酸杆菌数量及双歧杆菌/大肠杆菌比值高于对照组,大肠杆菌数量低于对照组(P<0.05)。结论:茵陈四苓散加减可以调节慢性乙肝患者肠道功能,重塑肠道菌群,有助于减少肠道内毒素吸收,从而减轻肝脏负担,保护肝功能,对抗乙肝病毒复制。
Objective:To study the mechanism of Yinchen Siling Powder on intestinal function and intestinal flora in patients with chronic hepatitis B.Methods:96patients with chronic hepatitis B were selected.According to the order of inclusion,they were divided into observation group and control group(48cases each)according to single and double numbers.The same basic treatment was used in the two groups.The observation group was combined with Yinchen Siqi powder for addition and subtraction,and 10days was a course of treatment for 3consecutive courses.The TCM symptoms,ALT,HBV serum markers,intestinal barrier function(DAO,D-lactic acid),intestinal flora status(such as bifidobacterium,Lactobacillus and Escherichia coli number,bifidobacterium/Escherichia coli ratio)were compared before treatment(T0)and at the end of treatment(T1).Results:The total effective rate of the observation group was 91.67%,higher than 72.92%of the control group(P<0.05).The scores of TCM symptoms and the levels of DAO and D-lactic acid at T1in both groups were significantly lower than those at T0(P<0.05);at T1,the scores of TCM symptoms and the levels of DAO and D-lactic acid in the observation group were lower than those in the control group(P<0.05).The number of Bifidobacterium,Lactobacillus and Bifidobacterium/Escherichia coli ratio increased and the number of Escherichia coli decreased in both groups at T1,but only in the observation group,the difference was statistically significant(P<0.05);and at T1,the number of Bifidobacterium,Lactobacillus and Bifidobacterium/Escherichia coli ratio in the observation group were higher thanthose in the observation group.The number of E.coli in the control group was lower than that in the control group(P<0.05).Conclusion:Yinchen Siling Powder can reduce the absorption of intestinal endotoxin,reduce the burden of liver,protect liver function and resist hepatitis B virus replication by regulating intestinal function and remodeling intestinal flora in patients with chronic hepatitis B.
作者
安永辉
孙燕
张雪
张小华
焦敏
An Yonghui;Sun Yan;Zhang Xue;Zhang Xiaohua;Jiao Min(Infection Department of Integrated Traditional Chinese and Western Medicine,Zhengzhou Sixth People's Hospital,Zhengzhou 450000,China)
出处
《亚太传统医药》
2020年第4期142-145,共4页
Asia-Pacific Traditional Medicine
关键词
茵陈四苓散
慢性乙肝
肠道功能
肠道菌群
作用机制
Yinchen Siling Powder
Chronic Hepatitis B
Intestinal Function
Intestinal Flora
Mechanism
