摘要
目的:分析我院2015-2018年度抗菌药物的使用强度与鲍曼不动杆菌的耐药性的关系。方法:统计2015年1月~2018年12月北京中医医院顺义医院抗菌药物的应用情况以及鲍曼不动杆菌的耐药性。鲍曼不动杆菌的耐药性资料来源于检验科临床送检的伤口分泌物、痰液、血液、尿液等病原学标本。结果:2015年~2018年,共分离到菌株13246株,其中分离到鲍曼不动杆菌株1927株,分离率为14.55%。其中2015年的分离率为3.11%,2016年的分离率为4.51%,2017年的分离率为5.15%,2018年的分离率为2.11%;鲍曼不动杆菌标本分离率最高的为痰液,占78.83%,其次为伤口分泌物,占12.51%,尿液标本占5.81%,血液标本占2.85%;鲍曼不动杆菌在我院所有致病菌中的排序均为第一位或者第二位;2015年~2018年抗菌药物的使用强度逐年升高,2018年有所降低;2015年~2018年鲍曼不动杆菌对哌拉西林钠他唑巴坦钠、美洛培南以及亚胺培南的耐药率均逐年升高,2018年有所降低;哌拉西林钠他唑巴坦钠、美洛培南以及亚胺培南的耐药性与抗菌药物使用强度之间具有明显的相关性(P<0.05)。结论:哌拉西林钠他唑巴坦钠、美洛培南以及亚胺培南的使用,是造成鲍曼不动杆菌耐药的重要原因之一,临床应加以重视。
Objective: To study the relationship between the use intensity of antibiotics and the resistance of Acinetobacter baumannii in our hospital from 2015 to 2018. Methods: The application of antibiotics in our hospital from January 2015 to December2018 and the resistance of Acinetobacter baumannii were analyzed. The drug resistance data of Acinetobacter baumannii come from the pathogenic samples such as wound secretion, sputum, blood, urine, etc. Results: From 2015 to 2018, a total of 13246 strains were isolated, of which 1927 strains were Acinetobacter baumannii, with the isolation rate of 14.55%. The separation rate was 3.11 % in 2015,4.51 % in 2016, 5.15 % in 2017 and 2.11 % in 2018. The highest isolation rate of Acinetobacter baumannii was sputum(78.83 %),followed by wound secretion(12.51 %), urine(5.81 %), blood(2.85 %). Acinetobacter baumannii ranked first or second among all pathogenic bacteria in our hospital;the use intensity of antibiotics increased year by year from 2015 to 2018, and decreased in 2018.From 2015 to 2018, the drug resistance rate of Acinetobacter baumannii to piperacillin, tazobactam, meropenem and imipenem increased year by year, and decreased in 2018, there was a significant correlation between the drug resistance of piperacillin, tazobactam and imipenem and the intensity of antimicrobial use(P<0.05). Conclusion: The use of piperacillin sodium, tazobactam sodium, meropenem and imipenem is one of the important reasons for resistance of Acinetobacter baumannii. We should pay attention to it in clinical practice.
作者
张慧
孙盼盼
纪润奇
胡杨杨
王霞
ZHANG Hui;SUN Pan-pan;JI Run-qi;HU Yang-yang;WANG Xia(Department of Laboratory,Shunyi Hospital,Beijing Chinese Medicine Hospital,Beijing,101300,China;Department of Laboratory,Beijing Shijitan Hospital Affiliated to Capital Medical University,Beijing,100038,China;Department of Laboratory,Beijing Chaoyang Hospital Affiliated to Capital Medical University,Beijing,100038,China;Department of Blood Transfusion,Beijing Tongren Hospital,Capital Medical University,Beijing,100730,China)
出处
《现代生物医学进展》
CAS
2020年第8期1511-1514,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(81371861)。
关键词
抗菌药物
使用强度
鲍曼不动杆菌
耐药性
Antibiotics
Use intensity
Acinetobacter baumannii
Drug resistance
