摘要
目的探讨无痛人工流产对患者围手术期血清应激指标及血流动力学指标的影响。方法按照随机数字表法将2016年1月至2017年1月于福建医科大学附属宁德市医院拟行人工流产的120例患者分为两组,观察组行无痛人工流产手术(n=60),对照组行普通人工流产手术(n=60),采用酶联免疫吸附法测定两组患者术前、术中5min及术后5min的促肾上腺皮质激素(ACTH)、血管紧张素-Ⅱ(Ang-Ⅱ)、皮质醇(Cor)、多巴胺(DA)、去甲肾上腺素(NA)等血清应激指标,同时监测收缩压(SBP)、舒张压(DBP)、血氧饱和度(SpO2)、心率(HR)等血流动力学指标。结果术中5min、术后5min,观察组患者血清ACTH、Ang-Ⅱ、Cor、DA、NA水平均低于对照组(t术中5min=4.382、4.097、3.665、3.904、4.197,t术后5min=3.289、3.912、3.508、4.102、3.689,均P<0.05);两组患者血清ACTH、Ang-Ⅱ、Cor、DA、NA水平均于术中5min、术后5min、术前依次降低(均P<0.05)。术中5min、术后5min,观察组患者SBP、DBP、HR、SpO2水平均高于对照组(t术中5min=3.907、4.562、4.108、3.346,t术后5min=2.981、3.342、3.645、3.297,均P<0.05);两组患者的SBP、DBP、HR、SpO2水平均于术中5min、术后5min、术前依次升高(均P<0.05)。结论无痛人工流产对围术期患者血清应激指标及血流动力学指标影响较小,有利于患者术后康复。
Objective To explore the effect of painless artificial abortion on the changes of serum stress indexes and hemodynamic parameters during perioperative period.Methods A total of 120 patients undergoing abortion in Ningde Hospital Affiliated of Fujian Medical University from January 2016 to January 2017 were divided into two groups according to the random number table method.The observation group underwent painless artificial abortion(n=60) while the control group underwent ordinary artificial abortion(n=60).The serum stress indexes including to adrenocorticotrophic hormone(ACTH),angiotensin-Ⅱ(Ang-Ⅱ),cortisol(Cor),dopamine(DA) and noradrenaline(NA) at preoperative,intraoperative 5 min and postoperative 5 min were examined by enzyme-linked immunosorbent assay.At the same time,the hemodynamic parameters including to systolic blood pressure(SBP),diastolic blood pressure(DBP),blood oxygen saturation(SpO2) and heart rate(HR) were dynamic monitored.Results At intraoperative 5 min and postoperative 5 min,the serum levels of ACTH,Ang-Ⅱ, Cor,DA and NA in observation group were all significantly lower than those in the control group(t values at intraoperative 5 min were 4.382,4.097,3.665,3.904 and 4.197,respectively,and t values at postoperative 5 min were 3.289,3.912,3.508,4.102 and 3.689,respectively,all P<0.05).The serum levels of ACTH,Ang-Ⅱ,Cor,DA and NA of two groups at intraoperative 5 min,postoperative 5 min and pre-operation were in turn lower(all P<0.05).At intraoperative 5 min and postoperative 5 min,the SBP,DBP,HR and SpO2 levels of the observation group were all higher than those of the control group(t values at intraoperative 5 min were 3.907,4.562,4.108 and 3.346,respectively,and t values at postoperative 5 min were 2.981,3.342,3.645,3.297,respectively,all P<0.05).The levels of SBP,DBP,HR and SpO2 of the two groups in intraoperative 5 min and postoperative 5 min and pre-operation increased successively(all P<0.05).Conclusion Painless artificial abortion has less effect on serum stress indexes and hemodynamic parameters in perioperative period,which is beneficial for postoperative rehabilitation.
作者
钟菊花
杨雷
吴兴花
江晓容
杨勇旺
ZHONG Juhua;YANG Lei;WU Xinghua;JIANG Xiaorong;YANG Yongwang(Department of Obstetrics and Gynecology,Ningde Hospital Affiliated of Fujian Medical University,Fujian Ningde 352100,China;Department of Anesthesilolgy,Ningde Hospital Affiliated of Fujian Medical University,Fujian Ningde 352100,China)
出处
《中国妇幼健康研究》
2020年第4期452-455,共4页
Chinese Journal of Woman and Child Health Research
关键词
无痛人工流产
应激反应
血流动力学
painless artificial abortion
stress indexes
hemodynamics
