摘要
目的探讨臭氧联合玻璃酸钠治疗膝骨性关节炎的临床疗效。方法膝关节骨性关节炎患者130例,按随机数字表法分为三组:玻璃酸钠组43例,在患者膝关节腔内注射玻璃酸钠25 mg;臭氧组44例,于膝关节腔内注射臭氧10 mL(浓度为20μg/mL);混合治疗组43例,第1、3周于膝关节腔内注射臭氧10 mL,第2、4周注射玻璃酸钠25 mg。每月共注射治疗4次。连续观察3个月后,比较3组患者的膝关节疼痛、关节功能、临床疗效及不良反应情况。结果治疗后3组患者的VAS评分均较治疗前降低,且混合组明显低于玻璃酸钠组、臭氧组(均P<0.05),但玻璃酸钠组与臭氧组比较差异无统计学意义(P>0.05)。混合组临床总有效率为97.67%,高于玻璃酸钠组的79.07%、臭氧组的75.00%(均P<0.05)。三组患者不良反应发生率差异无统计学意义(P>0.05)。结论臭氧联合玻璃酸钠治疗膝骨性关节炎有协同效应,可提高临床疗效。
Objective To explore the clinical efficacy of ozone combined with sodium hyaluronate for treating knee osteoarthritis. Methods A total of 130 patients with knee osteoarthritis were divided into three groups in accordance with the random number table method, the sodium hyaluronate group(43 cases) received intra-articular injection of 25 mg sodium hyaluronate, the ozone group(44 cases) received intra-articular injection of 10 mL ozone(at a concentration of 20 μg/mL), and the mixed treatment group(43 cases) received intra-articular injection of 10 mL ozone in the first and third week followed by intra-articular injection of 25 mg sodium hyaluronate in the second and forth week, with four-time injection per month in total. After three-consecutive-month observation, knee joint pain, knee joint function, clinical efficacy, and adverse reactions were compared between the three groups. Results After treatment, the VAS scores decreased in the three groups compared with the scores before treatment, and the scores in the mixed treatment group were lower than those in the sodium hyaluronate and ozone groups(all P<0.05), but there was no statistically significant difference between the sodium hyaluronate group and the ozone group(P>0.05). The total effective rate of the mixed treatment group(97.67%) was higher than that of the sodium hyaluronate(79.07%) and the ozone groups(75.00%)(all P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the three groups. Conclusion Ozone combined with sodium hyaluronate has a synergistic effect in the treatment of knee osteoarthritis, which can improve clinical efficacy.
作者
廖德发
王喜龙
张寿吉
付崇
覃莉珍
苏向东
覃荔
LIAO Defa;WANG Xilong;ZHANG Shouji;FU Chong;QIN Lizhen;SU Xiangdong;QIN Li(Department of Bone and Joint Rehabilitation,Guangxi Jiangbin Hospital&Guangxi Third People's Hospital,Nanning 530021,China)
出处
《微创医学》
2020年第2期158-161,共4页
Journal of Minimally Invasive Medicine
