摘要
目的探索转移性骨肿瘤患者的临床特征及用药不良事件发生的特点、规律,并据此探讨针对性干预措施。方法选取2002-2017年于余姚市中医医院进行治疗的583例转移性骨肿瘤患者的临床资料进行分析。统计此类患者的常见原发性肿瘤、骨转移部位,用药不良反应在各器官以及不同年龄阶段患者中的发生情况,发生药物不良反应的常见药物种类。结果转移性骨肿瘤患者的常见原发性肿瘤依次为肺癌(40.31%)、食管癌(10.12%)、乳腺癌(6.86%)、前列腺癌(6.52%)、肝癌(6.35%);骨转移常见部位分别是脊柱(72.04%)、肋骨(60.38%)、骨盆(34.82%)、胸骨(14.92%)和股骨(12.01%);共460例(78.90%)患者发生了2247次用药不良反应事件,用药不良反应最容易发生的部位依次为:胃肠道(24.12%)、皮肤(21.58%)、肝脏(16.29%)、肾脏(12.42%)、神经(6.72%);45~59岁患者用药不良反应发生率(40.44%)最高,男性药物不良反应发生率61.30%高于女性38.70%(χ^2=42.213,P=0.000);常见发生药物不良反应的药物种类依次为:植物来源抗肿瘤药物(20.07%)、抗生素(18.69%)和抗代谢药物(14.06%)。结论转移性骨肿瘤患者的临床特征、用药不良反应在不同年龄、性别患者中的表现具有不同的特点,可结合患者自身特质合理给药从而实现个体化给药。
Objective To understand the clinical characteristics and drug adverse events in patients with metastatic bone tumors in 2002-2017,and to discuss the specific intervention.Methods A retrospective study was conducted among 583patients with metastatic bone tumors treated in Yuyao Traditional Chinese Medicine Hospital from 2002to 2017.Their clinical data were analyzed including the common primary tumors,the location of bone metastases,the occurrence of adverse drug reactions in different organs and different ages as well as the common type of drugs.Results The most common primary tumor in patients with metastatic bone tumors was lung cancer(40.31%),followed by esophageal cancer(10.12%),breast cancer(6.86%),prostate cancer(6.52%)and liver cancer(6.35%).The most common bone location of bone metastasis is spine(72.04%),followed by rib(60.38%),pelvis(34.82%),sternum(14.92%)and femur(12.01%).A total of 2247adverse drug events were recorded in 460patients(78.90%).Gastrointestinal tract(24.12%)was found to be the most common site of adverse drug reactions,followed by skin(21.58%),liver(16.29%),kidney(12.42%)and nerve(6.72%).The incidence of adverse drug reactions was the highest of 40.44%in patients aged 45~59years and it was higher in males than in females(61.30%vs 38.70%;χ^2=42.213,P=0.000).The common drugs that caused adverse reactions were plant-derived antitumor drugs(20.07%),antibiotics(18.69%)and anti-metabolic drugs(14.06%).Conclusions The clinical features and adverse drug reactions in patients with metastatic bone tumors vary significantly among patients with different age and gender.Therefore,personalized drug administration should be adopted.
作者
邓成琼
张琦
黄李红
陈欢欢
姚艳红
DENG Cheng-qiong;ZHANG Qi;HUANG Li-hong;CHEN Huan-huan;YAO Yan-hong(Department of Orthopedics and Traumatology,Yuyao Hospital of Traditional Chinese Medicine,Yuyao,Zhejiang 315400,China)
出处
《中国预防医学杂志》
CAS
CSCD
2020年第1期94-97,共4页
Chinese Preventive Medicine
关键词
转移性骨肿瘤
临床特征
不良反应
抗肿瘤药
骨转移部位
原发性肿瘤
Metastatic bone tumors
Clinical characteristics
Adverse events
Antitumor drug
Site of bone metastasis
Primary tumor
