摘要
目的研究丹参多酚酸对于急性缺血性脑卒中患者脑灌注的改善作用以及可能的作用机制。方法选取2016年4月—2018年6月期间就诊的急性缺血性脑卒中患者150例,按照数字表法分为对照组和治疗组,每组75例。对照组采用内科常规治疗,治疗组在常规治疗的基础上给予丹参多酚酸。观察并比较两组患者神经功能损伤(NIHSS)评分和日常生活能力(ADL)评分及临床疗效。结果治疗14 d后,治疗组NIHSS评分明显低于对照组(P<0.05),ADL评分明显高于对照组(P<0.05),差异具有统计学意义。治疗组治疗后临床总有效率高于对照组(P<0.05),差异具有统计学意义。结论注射丹参多酚酸能够显著改善急性缺血性脑卒中患者神经功能缺损及日常生活能力,值得临床推广应用。
Objective To study the effect of salvianolic acid on cerebral perfusion in patients with acute ischemic stroke and its possible mechanism.Methods 150 patients with acute ischemic stroke who were treated in our hospital from April 2016 to June 2018 were randomly divided into control group and treatment group according to the digital table method.75 patients in each group.The control group was treated only by routine medical treatment,while the treatment group was given additional intravenous drip of salvianolic acid on the basis of routine treatment.The neurological impairment(NIHSS),daily living ability(ADL)and clinical efficacy were observed and compared between the two groups.Results Before treatment,there was no significant difference in NIHSS between the two groups(P>0.05).After 14 days of treatment,the score of the treatment group was significantly lower than that of the control group(P<0.05).Before treatment,there was no significant difference in ADL score between the two groups(P>0.05).After 14 days of treatment,the ADL score of the treatment group was significantly higher than that of the control group,with statistical significance(P<0.05).The total clinical effective rate of the treatment group was higher than that of the control group,with statistical significance(P<0.05).Conclusions Salvia miltiorrhiza polyphenolic acid injection can significantly improve cerebral perfusion in patients with acute ischemic stroke,significantly improve neurological deficits,and significantly improve the daily independent living ability of patients,which is worthy of clinical recommendation and application.
作者
范崇桂
付国惠
闪海霞
张保朝
邢娟
李新月
FAN Chong-gui;FU Guo-hui;SHAN Hai-xia;ZHANG Bao-chao;XING Juan;LI Xin-yue(Department of Neurology,Nanyang Central Hospital,Nanyang Henan 473000)
出处
《世界中西医结合杂志》
2020年第5期939-942,共4页
World Journal of Integrated Traditional and Western Medicine
基金
河南省中医药科学研究专项课题(2013ZYM02005)。
关键词
急性缺血性脑卒中
丹参多酚酸
神经功能
日常生活能力
Acute ischemic stroke
Salvia polyphenolic acid
Neurological function
Daily life ability
