摘要
目的:探究融合基因动态检测在儿童急性淋巴细胞白血病治疗过程中的意义。方法:2011年8月-2016年6月收治初发儿童急性淋巴细胞白血病患者200例,统计所有患者在治疗前后融合基因的表达情况,分析融合基因表达与急性淋巴细胞白血病预后的关系。结果:在所有急性淋巴细胞白血病基因表达中,融合基因阳性对生存率无明显影响,差异无统计学意义(P>0.05)。对无事件生存率有显著影响,差异有统计学意义(P<0.05)。TEL-AML1、其他融合基因转阴患者3年无事件生存率较未转阴患者高,融合基因1年内的转阴情况对患者3年无事件生存率无显著影响,差异有统计学意义(P<0.05)。结论:融合基因动态监测对于儿童急性淋巴细胞白血病的判断与预后有非常重要的意义。
Objective:To explore the significance of dynamic detection of fusion gene in the treatment of childhood acute lymphoblastic leukemia.Methods:From August 2011 to June 2016,200 children with primary acute lymphoblastic leukemia were admitted,the expression of fusion gene in all patients before and after treatment was analyzed,we analyzed the relationship between the expression of fusion gene and the prognosis of acute lymphoblastic leukemia.Results:In all acute lymphoblastic leukemia gene expressions,the positive fusion gene had no significant effect on survival rate,and the difference was not statistically significant(P>0.05),there was a significant effect on event free survival,the difference was statistically significant(P<0.05).The 3-year event-free survival rate of patients with TEL-AML1 and other fusion genes was higher than that of patients without conversion,the negative conversion of fusion gene within 1 year had no significant effect on the 3-year event-free survival rate,the differences were statistically significant(P<0.05).Conclusion:The dynamic monitoring of fusion gene is very important for the judgment and prognosis of childhood with acute lymphoblastic leukemia.
作者
王平
Wang Ping(The People's Hospital of Wushan County,Chongqing City,Chongqing 404700)
出处
《中国社区医师》
2020年第16期117-117,119,共2页
Chinese Community Doctors
