摘要
目的研究分泌型卷曲相关蛋白5(SFRP5)水平对于妊娠期糖尿病(GDM)患者不同妊娠并发症相关研究。方法选择妊娠分娩的GDM患者250例作为观察组,选择同一时期妊娠分娩的健康孕妇100例作为对照组,所有孕妇在孕24~28周确诊是否患有GDM后,行SFRP5、空腹血糖(FBG)、餐后2 h血糖(2hPBG)、糖化血红蛋白(HbA1c)检查。比较2组、OGTT两项及以上异常组和单纯FBG升高组孕妇的FBG、2 hPBG、HbA1c、SFRP5水平和妊娠结局。比较不同SFRP5水平孕妇各种不良妊娠结局发生率。观察SFRP5和FBG、2 hPBG、HbA1c及各种不良妊娠结局发生率的相关性。结果观察组患者SFRP5水平低于对照组,单纯FBG升高组患者SFRP5水平高于OGTT两项及以上升高组,差异均有统计学意义(P<0.05)。对照组患者总计发生妊娠并发症及不良结局发生率、总计发生新生儿并发症发生率均低于观察组(P<0.05),单纯FBG升高组患者总计发生妊娠并发症及不良结局发生率、OGTT两项及以上升高组总计发生新生儿并发症发生率均低于OGTT两项及以上升高组(P<0.05),SFRP5水平与HbA1c呈负相关(r=-0.742,P<0.05),SFRP5与巨大儿,新生儿低血糖,妊娠期高血压疾病,羊水过多,呼吸窘迫综合征呈负相关(r值分别为-0.859、-0.711、-0.649、-0.713、-0.646,P<0.05)。结论SFRP5水平与巨大儿,新生儿低血糖,妊娠期高血压疾病,羊水过多,呼吸窘迫综合征发生呈负相关。对于GDM患者的妊娠结局具有重要的预测价值。
Objective To investigate the effects of secretory curl associated protein 5(SFRP5)on pregnancy complications in patients with gestational diabetes mellitus(GDM).Methods A total of 250 pregnant women with gestational diabetes were enrolled as observation group,at the same time,the other 100 healthy pregnant women were enrolled as control group.All the pregnant women were examined for SFRP5,FBG,2hPBG and HbA1c at 24~28 weeks after gestation.The levels of FBG,2hPBG,HbA1c,SFRP5 and pregnancy outcome were observed and compared between the two groups.Moreover,the incidences of adverse pregnancy outcomes in the pregnant women with different SFRP5 levels were observed and compared.Furthermore,the correlation between SFRP5 and FBG,2hPBG,HbA1c,as well as the incidence of adverse pregnancy outcomes was analyzed.Results The SFRP5 levels in observation group were significantly lower than those in control group,and the SFRP5 levels in elevated FBG group were significantly higher than those in multiple-elevated OGTT group(P<0.05).Moreover,the incidences of pregnancy complications,adverse outcomes and neonatal complications in control group were significantly lower than those in observation group(P<0.05).The incidences of pregnancy complications,adverse outcomes in elevated FBG group and the total incidence of neonatal complications in multiple-elevated OGTTgroup were significantly lower than those in multiple-elevated OGTT group(P<0.05).In addition,the SFRP5 levels were not only negatively correlated with those HbA1c(P<0.05),but also with macrosomia,neonatal hypoglycemia,hypertensive disorder complicating pregnancy,polyhydramnios and respiratory distress syndrome(P<0.05).Conclusion The SFRP5 levels are negatively correlated with macrosomia,neonatal hypoglycemia,hypertensive disorder complicating pregnancy,polyhydramnios and respiratory distress syndrome,which is of important value in predicting the pregnancy outcome of patients with gestational diabetes.
作者
孙东华
闫芳
陈凤玲
杨洪英
郭冬青
SUN Donghua;YAN Fang;CHEN Fengling(The Fourth People’s Hospital of Hengshui City, Hebei,Hengshui 053000,China)
出处
《河北医药》
CAS
2020年第11期1641-1644,共4页
Hebei Medical Journal
关键词
分泌型卷曲相关蛋白5
妊娠期糖尿病
妊娠结局
secretory curl associated protein 5
gestational diabetes mellitus
pregnancy outcome
