摘要
目的探讨与分析骨良性纤维组织细胞瘤的影像学及病理学特征。方法选择骨良性纤维组织细胞瘤患者80例,所有患者行X线、CT与MRI检查,同时行病理学检查与免疫组化分析。结果在80例患者中,病灶位于长骨32例,股骨28例,胫骨15例,肱骨3例,桡骨2例;所有病灶均成不同程度的膨胀性骨质破坏,CT比X线平片更清楚地显示骨质破坏的程度、范围及边界情况,MRI显示病灶均呈膨胀性骨质破坏。病理学HE染色显示肿瘤大体呈黄色、棕红色、灰色不规则团块状,免疫组化显示所有患者病理组织CD68与Vementin表达阳性,S-100、P63与CD34都表达阴性。结论骨良性纤维组织细胞瘤在影像学上主要表现为囊状、膨胀性骨质破坏,病理上表现为CD68与Vementin表达阳性,其诊断需要结合临床、组织病理学、影像学等多方面信息进行综合判断。
Objective To investigate and analyze the imaging and pathological features of benign fibrous histiocytoma of bone.Methods 80 patients with benign fibrous histiocytoma of the bone were selected.All patients were given X-ray,CT and MRI,and pathological examination and given immunohistochemistry analysis.Results In the 80 patients,there were 32 patients were in long bone,28 patients in femur,15 patients in tibia,3 patients in tibia,and 2 patientsin in humerus.All lesions had different degrees of expansive bone destruction.CT was more common than X-ray film and were clearly showed the extent and boundary of bone destruction,MRI showed swelling of the lesions.Pathological HE staining showed that the tumor was generally yellow,brownish red and gray irregularly.Immunohistochemistry showed that all patients had positive expression of CD68 and Vementin in pathological tissues,and negative expression of S-100,P63 and CD34.Conclusion The benign fibrous histiocytoma of the bone was mainly characterized by cystic and expansive bone destruction.The pathological manifestations were positive for CD68 and Vementin.The diagnosis requires comprehensive judgment in combination with clinical,histopathology,imaging and other aspects.
作者
王雯
张建巧
李晓菊
WANG Wen;ZHANG Jianqiao;LI Xiaoju(Shangluo Center Hospital,Shangluo,726000)
出处
《实用癌症杂志》
2020年第6期907-909,913,共4页
The Practical Journal of Cancer
基金
国家级协作科研项目(编号:W2013GJ22)。
