摘要
目的观察消化内镜联合四联疗法对胃溃疡伴活动性出血的治疗效果,并分析其再出血的相关危险因素。方法选取2016年9月至2018年9月焦作煤业集团有限责任公司中央医院消化科收治的88例胃溃疡伴活动性出血患者作为研究对象,并按照随机数表法将其随机分为观察组与对照组,每组44例,观察组患者采用消化内镜联合四联疗法治疗,对照组患者单纯采用四联疗法治疗,对比两组患者的临床疗效,观察两组患者治疗后再出血的发生情况,并分析再出血的相关危险因素。结果治疗2周后,观察组患者的临床疗效明显优于对照组(Mann-Whitney U=708.500,Z=-2.380,P=0.017);经多因素Logistic回归分析发现,血红蛋白含量低、溃疡为A1期及未联合消化内镜治疗是患者再出血的独立危险因素(OR=1.792、1.165、1.879,P=0.015、0.022,0.031)。结论胃溃疡伴活动性出血患者应用消化内镜联合四联疗法治疗,可有效提高治疗效果,降低再出血发生率,且患者血红蛋白含量低及溃疡为A1期也是胃溃疡伴活动性出血患者再出血的独立危险因素,应加以重视。
Objective To observe the curative effect of digestive endoscopy combined with quadruple therapy in the treatment of gastric ulcer with active bleeding and analyze the related risk factors for ulcer rebleeding.Methods 88 patients suffering from gastric ulcers combined with active bleeding,admitted to Department of Gastroenterology,the Central Hospital of Jiaozuo Coal Industry Group Co.,Ltd.from September 2016 to September 2018,were selected as research subjects,and then divided,according to random number table,into an observation group(44 cases) and a control group(44 cases).Patients in the observation group were treated with digestive endoscopy combined with quadruple therapy,while patients in the control group were treated with quadruple therapy only.The curative effect was compared between the two groups,the occurrence of rebleeding after treatment in the two groups was observed,and the related risk factors for ulcer rebleeding were analyzed.Results After 2 weeks of treatment,the curative effect of the observation group was significantly better than the control group(Mann-Whitney U=708.500,Z=-2.380,P=0.017);it was found with multivariate logistic regression analysis that independent risk factors for ulcer rebleeding were:low hemoglobin content,ulcer at A1 stage,and no digestive endoscopy in the treatment(OR=1.792,1.165,1.879,P=0.015,0.022,0.031).Conclusion Use of Digestive endoscopy combined with quadruple therapy in patients with gastric ulcers and active bleeding can improve therapeutic effect and reduce the incidence of rebleeding.Moreover,the low hemoglobin content and ulcer being at A1 stage are also independent risk factors for ulcer rebleeding,which should be taken seriously.
作者
王中良
许贺春
白洁
Wang Zhongliang;Xu Hechun;Bai Jie(Department of Gastroenterology,Central Hospital of Jiaozuo Coal Industry Group co,LTD,Jiaozuo City,Henan 454000,China)
出处
《中国烧伤创疡杂志》
2020年第3期214-217,共4页
The Chinese Journal of Burns Wounds & Surface Ulcers
关键词
消化内镜
四联疗法
胃溃疡
活动性出血
再出血
危险因素
Digestive endoscopy
Quadruple therapy
Gastric ulcer
Active bleeding
Rebleeding
Risk factors
