摘要
黏着斑激酶(FAK)是一种非受体型酪氨酸激酶,广泛分布于体内多种细胞的胞质中,能够传递来自细胞膜受体、整合素以及细胞间生长因子的信号,参与调控细胞生长与分化、黏附与迁移、增殖与凋亡等重要生物学过程。FAK在许多相互独立的疾病中扮演了重要角色,眼科也不例外,笔者就FAK的一般特性及其在常见眼病中的作用进行综述,以期揭示这些疾病新的发病机制,为寻找更为有效的防治方法提供新思路。
Focal adhesion kinase(FAK)is a non-receptor tyrosine kinase,widely distributed in the cytoplasm of cells in the body.It can transmit signals from cell membrane receptors and intercellular growth factors,and participate in the regulation of cell growth and differentiation,adhesion and migration,proliferation and apoptosis,and other important biological processes.FAK is at the intersection of many signal transduction pathways in cells,and researchers have confirmed that it plays an important role in many systemic diseases.This review summarizes the general characteristics of FAK and its functions in ophthalmic diseases.
作者
汤文权
曹梦丹
周灯明
潘政
段宣初
Wenquan Tang;Mengdan Cao;Dengming Zhou;Zheng Pan;Xuanchu Duan(Department of Ophthalmology,The Second Xiangya Hospital of Central South University,Changsha 410011,China;Department of Ophthalmology,Hunan Province Children's Hospital,Changsha 410007,China;Hunan Clinical Research Center for Ocular Surface Diseases,Changsha Aier Eye Hospital,Changsha 410015,China)
出处
《中华眼视光学与视觉科学杂志》
CAS
CSCD
2020年第5期397-400,共4页
Chinese Journal Of Optometry Ophthalmology And Visual Science
基金
国家自然科学基金项目(81670859)。
关键词
黏着斑激酶
眼胚发育
白内障
青光眼
玻璃体视网膜疾病
角膜病
focal adhesion kinase
ocular embryogenesis
cataract
glaucoma
vitreoretinal diseases
corneal diseases
