摘要
非酒精性脂肪性肝炎和非酒精性脂肪性肝病(NAFLD)在20世纪80年代首次用于描述肝组织学改变与酒精性肝病相似但患者无过量饮酒且无其他损肝因素存在。40年来,NAFLD的研究越来越深入且进展迅速。然而,一直未变的NAFLD命名对日常临床实践和当前临床试验已产生了一定的阻碍。为了克服旧术语的缺陷,日前国际共识小组建议应用代谢相关脂肪性肝病(MAFLD)取代NAFLD,并进一步提出既全面又简便的MAFLD新定义用于临床诊断,从而使MAFLD有别于其他肝脏疾病;同时,建议MAFLD的疾病评估和严重程度分层应该超出当前的二分类法则。NAFLD更名为MAFLD将成为优化临床实践,提高临床研究效率,并使医生、患者群体获益的一项重要举措。
The terms nonalcoholic steatohepatitis and nonalcoholic fatty liver disease(NAFLD)were first used in the 1980s to describe a condition of similar liver histological changes to alcoholic liver disease,without excessive drinking nor other factors for liver injury.In-depth research on NAFLD has achieved rapid progress over the past 40 years;however,the unchanged nomenclature of the disease has become an obstacle for routine clinical practice and clinical trials.To overcome the shortcomings of the old term,the international consensus panel proposes to use the term metabolic associated fatty liver disease(MAFLD)to replace NAFLD and further puts forward the comprehensive and simple definition of MAFLD for clinical diagnosis,which makes MAFLD different from other liver diseases.Meanwhile,the panel suggests that MAFLD assessment and severity stratification should be extended beyond the simple dichotomous classification used at present.The new name MAFLD will become an important measure for optimizing clinical practice and improving clinical research and may bring benefits to physicians and patients.
作者
曾静
范建高
ZENG Jing;FAN Jiangao(Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China;Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai 200092, China)
出处
《临床肝胆病杂志》
CAS
北大核心
2020年第6期1205-1207,共3页
Journal of Clinical Hepatology
基金
国家科技部精准诊疗课题(2017YFC0908900)
国家自然科学基金(81873536)
上海市领军人才培养计划(2017019)
上海交通大学医学院高水平地方高校创新团队(2018)。
