摘要
目的分析细胞核抗原抗体Ki-67、趋化因子受体4(CXCR4)与甲状腺癌(TC)患者相关病理学参数的关联性。方法选取2016年5月至2019年4月本院72例TC组织标本为TC组,另选取同期36例甲状腺肿组织标本为良性组。以免疫组织化学法测定两组标本Ki-67、CXCR4表达情况,分析其表达与TC病理学特征的关联性。结果TC组Ki-67、CXCR4阳性表达率分别为69.44%(50/72)、76.39%(55/72),均高于良性组5.56%(2/36)、33.33%(12/36),差异均有统计学意义(均P<0.05);Ⅲ~Ⅳ期TC患者Ki-67阳性表达率87.88%(29/33),高于Ⅰ~Ⅱ期53.85%(21/39),淋巴结转移TC患者Ki-67阳性表达率84.38%(27/32),高于非淋巴结转移TC患者57.50%(23/40),Ⅲ~Ⅳ期TC患者CXCR4阳性表达率93.94%(31/33),高于Ⅰ~Ⅱ期61.54%(24/39),淋巴结转移TC患者CXCR4阳性表达率96.88%(31/32),高于非淋巴结转移TC患者60.00%(24/40),差异均有统计学意义(均P<0.05)。结论Ki-67、CXCR4在TC中阳性表达率高,均与TC临床分期、淋巴结转移有密切关系,是诊断TC患者病情的重要指标,有利于指导临床治疗、评估预后。
Objective To analyze the relationship between nuclear antigen antibody Ki-67 and chemokine receptor 4(CXCR4)on one hand and pathological parameters on the other hand in patients with thyroid carcinoma(TC).Methods 72 TC tissue samples from our hospital were selected as a TC group,and 36 benign samples a benign group.The expressions of Ki-67 and CXCR4 in the two groups were detected by immunohistochemistry.And the correlation between the expressions and the pathological characteristics of TC was analyzed.Results The positive expression rates of Ki-67 and CXCR4 were 69.44%(50/72)and 76.39%(55/72)in the TC group,and were 5.56%(2/36)and 33.33%(12/36)in the benign group(both P<0.05).The positive expression rate of Ki-67 was 87.88%(29/33)in the patients with stageⅢ-ⅣTC,and was 53.85%(21/39)in the patients with stageⅠ-ⅡTC(P<0.05).The positive expression rate of Ki-67 was 84.38%(27/32)in the patients with lymph node metastasis,and was 57.50%(23/40)in the patients with no lymph node metastasis(P<0.05).The positive expression rate of CXCR4 was 93.94%(31/33)in patients with stageⅢ-ⅣTC,and was 61.54%(24/39)in the patients with stageⅠ-ⅡTC(P<0.05).The positive expression rate of CXCR4 was 96.88%(31/32)in the patients with lymph node metastasis,and was 60.00%(24/40)in the patients with no lymph node metastasis(P<0.05).Conclusion The high positive expression rates of Ki-67 and CXCR4 in TC are closely related to the clinical stage and lymph node metastasis of TC.They are important indicators for the diagnosis of TC,and are helpful to guide clinical treatment and evaluate prognosis.
作者
郑会爽
尹婷婷
张莉伟
马洪林
Zheng Huishuang;Yin Tingting;Zhang Liwei;Ma Honglin(Department of Pathology,Haiyang People's Hospital,Haiyang 265100,China)
出处
《国际医药卫生导报》
2020年第12期1716-1719,共4页
International Medicine and Health Guidance News
