摘要
呼吸道合胞病毒(RSV)是世界范围内重要的病毒性病原体,因儿童的免疫特异性及肺部解剖特异性等原因,导致其感染RSV所致毛细支气管炎的发病率和病死率较高,治疗及预防毛细支气管炎成为儿科工作亟待解决的问题。毛细支气管炎是婴幼儿易患的下呼吸道炎症,也称为喘憋性肺炎,近来研究发现间充质干细胞(MSC)在体内多个脏器中表达,包括肺脏,其可通过多种方式来减轻炎症反应并减少炎性细胞因子的释放,还具有一定的修复损伤功能,这对毛细支气管炎的治疗提供了理论依据。本文就间充质干细胞对RSV致毛细支气管炎治疗及预防作用的研究进展做一概述。
Respiratory syncytial virus(RSV)is an important viral pathogen in the world.Due to children’s immunological specificity and pulmonary anatomical specificity,the incidence and mortality of bronchiolitis caused by RSV are high.Therefore,the treatment and prevention of bronchiolitis have become urgent problems to be solved in pediatrics.Capillary bronchitis are predisposed to lower respiratory tract inflammation for infants and young children,also known as asthma suppress pneumonia.Recent studies have found mesenchymal stem cells(MSC)expressed in multiple organs in the body,including lung;it can reduce the inflammatory response and the release of inflammatory cytokines through a variety of ways,also has certain repair injury function,which provides a theoretical basis for the treatment of capillary bronchitis.This paper reviews the progress in the treatment and prevention of RSV-induced bronchitis by mesenchymal stem cells.
作者
史洋洋
吴福玲
Shi Yangyang;Wu Fuling(Department of Pediatrics,Hospital Affiliated to Binzhou Medical University,Binzhou 256600,China)
出处
《国际医药卫生导报》
2020年第12期1798-1801,共4页
International Medicine and Health Guidance News
关键词
间充质干细胞
毛细支气管炎
呼吸道合胞病毒
Mesenchymal stem cells(MSC)
Bronchiolitis
Respiratory syncytial virus(RSV)
