摘要
骨质疏松症的发病率逐年上升,给社会带来沉重的经济负担。围绝经期女性由于体内激素水平的变化以及衰老的作用更易罹患骨质疏松症。其潜在的机制通常归因于雌激素缺乏,而骨质丢失往往始于绝经状态及雌激素缺乏之前。卵泡刺激素(FSH)于绝经前6年开始上升,且与骨密度呈负相关,可能为围绝经期骨质丢失的原因之一。FSH不仅通过FSH受体(FSHR)作用于性腺组织,同时也作用于破骨细胞参与骨代谢。FSH可通过信号传导通路、细胞因子、免疫因素等多种途径促进破骨细胞的生成、成熟与分化。本文主要就FSH对围绝经期骨质疏松症的影响、相关作用机制及其临床应用进行讨论,以期为围绝经期女性骨质疏松症的预防和治疗提供新思路。
The incidence of osteoporosis is increasing year by year,causing economic burden to the society.Peri-menopausal women are more susceptible to osteoporosis due to serum hormone level and aging.Until recently,the underlying mechanisms have been primarily attributed to estrogen deficiency,but bone loss in women commences is prior to the onset of menopause and estrogen deficiency.The level of serum FSH increases as early as 6 years before the final menstrual period.Several studies have found that FSH is correlated with bone turnover markers and bone mineral density,which may be one of the causes of peri-menopausal bone loss.FSH not only acts on gonads through FSH receptors(FSHR),but also acts on osteoclasts and bone metabolism.FSH promotes osteoclasts formation,maturation and differentiation through signaling pathways,cytokines and immune factors.This article mainly reviews the relationship,the mechanism,the clinical application between FSH and peri-menopausal osteoporosis,which aims to provide new ideas for the prevention and treatment of perimenopausal osteoporosis.
作者
杜旖旎
王雪
陈怡洁
贾涔琳
黄坚
金雪静
张治芬(审校)
DU Yi-ni;WANG Xue;CHEN Yi-Jie;JIA Cen-lin;HUANG Jian;JIN Xue-jing;ZHANG Zhi-fen(Nanjing Medical University,Nanjing 211166,China;Zhejiang Chinese Medical University,Hangzhou 310000,China;Hangzhou Women′s Hospital,Hangzhou 310006,China)
出处
《国际妇产科学杂志》
CAS
2020年第3期297-300,共4页
Journal of International Obstetrics and Gynecology
基金
杭州市医药卫生科技(重点)项目(2011Z003)
浙江省科技计划项目(2017C33203)。
关键词
围绝经期
骨质疏松
卵泡刺激素
骨密度
破骨细胞
Perimenopause
Osteoporosis
Follicle stimulating hormone
Bone mineral density
Osteoclasts
